A Porcine Model of Acute Lung Injury by Instillation of Gastric Fluid

Respiratory consequences of perioperative complications related to anaesthesia

“…In agreement with the findings of the few previous studies in which the mechanical changes were assessed for both lungs together in various animal models, we observed an acute deterioration in the lung tissue mechanics in the aspirated lung (Ko et al, 2008;Meers et al, 2011;. This adverse change can be attributed to pulmonary oedema due to the increased vascular permeability (Goldman et al, 1993;Grimbert et al, 1981;Ko et al, 2008), surfactant dysfunction (Davidson et al, 2005;Lamonica et al, 2014) and inflammation (Knight et al, 1992;Nader-Djalal et al, 2007).…”

“…The model applied in the present study mimics the most important clinical features of bronchoaspiration, such as bronchospasm and atelectasis development leading to impaired oxygenation. However, the effects of aspiration on the lung oxygenation and on the systemic haemodynamics in the present study were less severe in magnitude than those obtained earlier (Meers et al, 2011). A plausible explanation for this apparent discrepancy may be the unilateral aspiration applied in the current experiments.…”

“…Since all of these processes promote the development of atelectasis leading to a lung volume loss, the elevations in the unilateral G and H in the aspirated lungs are likely to occur subsequently to this phenomenon. The scarce earlier results indicated similar detrimental changes in the total resistive properties of the pulmonary system (Kuckelt et al, 1979;Meers et al, 2011;Tuchman et al, 1984). However, we are unaware of any previous studies assessing changes in airway mechanics following acid aspiration.…”

“…5). This may be subsequent to the localized deposition of the instilled gastric juice (Amigoni et al, 2008;Meers et al, 2011), which compromised the regional ventilation in these patchy lung areas.…”

A Model of Ex Vivo Perfusion of Porcine Donor Lungs Injured by Gastric Aspiration: A Step Towards Pretransplant Reconditioning

“…In a previous study, we already developed a lung injury model by aspiration of gastric juice [15] as a first step to study reconditioning of injured lungs during EVLP. In that study, data on the effect of aspiration on pulmonary function in the donor animal prior to explantation and EVLP were described.…”