A porcine model for acute ischaemic right ventricular dysfunction

Haraldsen, Pernille; Lindstedt, Sandra; Metzsch, Carsten; Algotsson, Lars; Ingemansson, Richard

doi:10.1093/icvts/ivt418

Cited by 8 publications

(6 citation statements)

References 23 publications

(32 reference statements)

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“…The decrease in SMA flow in the intervention groups followed the decrease in CI, but the SMA flow was higher than predicted at CO 50% (61% [48–73] and 60% [53–70]) in the tamponade and caval vein groups, respectively) and lower at CO 35% (17% and 24% [19–36] in the tamponade and caval vein groups, respectively; Figs. 2e and 3).…”

Section: Resultsmentioning

confidence: 82%

“…In contrast to models of low CO induced by cardiac ischemia [14, 16, 17, 19, 32], neither of the presented models mirrors cardiac dysfunction with load-independent decreased contractility, which would have been a disadvantage if the cardiac function per se was the subject matter. However, from the perspective of the intestines, both mimic a combined backward and forward cardiac failure, which makes the models highly clinically relevant for gastrointestinal consequences of cardiac dysfunction.…”

Section: Discussionmentioning

confidence: 77%

“…Several experimental models for creating acute cardiac dysfunction and low CO by myocardial injury have been described, including percutaneous injections of microspheres [14] or ethanol in a coronary artery [15], percutaneous balloon occlusion [16], or ligation of one or several coronary arteries [17–19]. Although clinically relevant, one disadvantage of these models is that CO cannot easily be titrated to a preset level.…”

Section: Introductionmentioning

confidence: 99%

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Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

Seilitz

Hörer

Skoog

et al. 2018

J. of Cardiovasc. Trans. Res.

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The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade ( n = 6) or partial inferior caval vein balloon inflation ( n = 6), CO was controllably reduced for 1 h each to 75% (CO 75% ), 50% (CO 50% ), and 35% (CO 35% ) of the baseline value. Cardiac output in controls ( n = 6) was not manipulated and maintained. Mean arterial pressure, superior mesenteric arterial blood flow, and intestinal mucosal perfusion started to decrease at CO 50% in the intervention groups. The decrease in superior mesenteric arterial blood flow was non-linear and exaggerated at CO 35% . Systemic, venous mesenteric, and intraperitoneal lactate concentrations increased in the intervention groups from CO 50% . Global and mesenteric oxygen uptake decreased at CO 35% . In conclusion, gastrointestinal metabolism became increasingly anaerobic when CO was reduced by 50%. Anaerobic gastrointestinal metabolism in low CO can be detected using intraperitoneal microdialysis.

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Section: Resultsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

Seilitz

Hörer

Skoog

et al. 2018

J. of Cardiovasc. Trans. Res.

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show abstract

“…This model is therefore reasonable for investigations of drug effects on the gastrointestinal tract. Other relevant models include induction of cardiac tamponade, direct aortic, or mesenteric in-flow restriction and open-and closed-chest models of acute cardiac ischemia (15,(22)(23)(24)(25)(26). However, in this study, the intention was to induce and maintain a predetermined level of CO, which was accomplished, to isolate peripheral vasoactive effects from inotropy.…”

Section: The Experimental Modelmentioning

confidence: 99%

A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract

Seilitz

Grafver

Kiszakiewicz

et al. 2021

Shock

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Background: Splanchnic vasodilation by inodilators is an argument for their use in critical cardiac dysfunction. To isolate peripheral vasoactivity from inotropy, such drugs were investigated, and contrasted to vasopressors, in a fixed low cardiac output (CO) model resembling acute cardiac dysfunction effects on the gastrointestinal tract. We hypothesized that inodilators would vasodilate and preserve the aerobic metabolism in the splanchnic circulation in low CO. Methods: In anesthetized pigs, CO was lowered to 60% of baseline by partial inferior caval vein balloon inflation. The animals were randomized to placebo (n = 8), levosimendan (24 μg kg −1 bolus, 0.2 μg kg −1 min −1 , n = 7), milrinone (50 μg kg −1 bolus, 0.5 μg kg −1 min −1 , n = 7), vasopressin (0.001, 0.002 and 0.006 U kg −1 min −1 , 1 h each, n = 7) or norepinephrine (0.04, 0.12, and 0.36 μg kg −1 min −1 , 1 h each, n = 7). Hemodynamic variables including mesenteric blood flow were collected. Systemic, mixed-venous, mesenteric-venous, and intraperitoneal metabolites were analyzed. Results: Cardiac output was stable at 60% in all groups, which resulted in systemic hypotension, low superior mesenteric artery blood flow, lactic acidosis, and increased intraperitoneal concentrations of lactate. Levosimendan and milrinone did not change any circulatory variables, but levosimendan increased blood lactate concentrations. Vasopressin and norepinephrine increased systemic and mesenteric vascular resistances at the highest dose. Vasopressin increased mesenteric resistance more than systemic, and the intraperitoneal lactate concentration and lactate/pyruvate ratio. Conclusion: Splanchnic vasodilation by levosimendan and milrinone may be negligible in low CO, thus rejecting the hypothesis. High-dose vasopressors may have side effects in the splanchnic circulation.

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“…Seven domestic Landrace pigs (72 ±6 kg) were used in the experiment and seven domestic Landrace pigs (73 ±12 kg) previously used for developing the experimental model were used as controls. 38 Both experiments were conducted during the same time period.…”

Section: Animalsmentioning

confidence: 99%

Sevoflurane anesthesia during acute right ventricular ischemia in pigs preserves cardiac function better than propofol anesthesia

et al. 2016

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A porcine model for acute ischaemic right ventricular dysfunction

Abstract: This novel open-chest porcine model of induced ischaemia of the right ventricular free wall resulted in significant haemodynamic compromise confirmed using standard haemodynamic measurements making it useful for further research on acute, ischaemic isolated right ventricular failure.

Cited by 8 publications

References 23 publications

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract

Sevoflurane anesthesia during acute right ventricular ischemia in pigs preserves cardiac function better than propofol anesthesia

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