A Population Study on the Relationship Between Blood Pressure and the Excretion of Urinary Cations

Staessen, Jan A; Fagard, Robert; Lijnen, Paul; Amery, A

doi:10.1097/00005344-198400061-00033

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“…Numerous studies in both humans and animal models of hypertension have demonstrated that urinary calcium excretion is increased following a high salt diet. 15,24,[35][36][37][38] This association appears to be dependent on a state of saltsensitivity. 9,10,39 For example, Weinberger et al 10 observed that calcium supplement was associated with a significant reduction in blood pressure only in African Americans and individuals prone to salt-sensitivity.…”

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confidence: 99%

Differential Effect of Renal Cortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-Sensitive Hypertension

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Anderson

et al. 2014

American Journal of Hypertension

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We interpret these findings to suggest that decreased renal cortical ISF(Ca)(2+) plays a role in the increase in blood pressure following a high salt diet in salt hypertension perhaps by mediating renal vasoconstriction; the role of medullary calcium remains to be fully understood. Further studies are needed to determine the mechanism of the altered renal ISF(Ca)(2+) and its role in blood pressure regulation.

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