A Population Physiologically‐Based Pharmacokinetic Model to Characterize Antibody Disposition in Pediatrics and Evaluation of the Model using Infliximab
Abstract:Aims: In order to better predict the pharmacokinetics (PK) of antibodies
in children, and to facilitate dose optimization of antibodies in
pediatric patients, there is a need to develop systems PK models that
integrate ontogeny related changes in human physiological parameters.
Methods: A population-based physiological-based PK (PBPK) model to
characterize antibody PK in pediatrics has been developed, by
incorporating age-related changes in body weight, organ weight, organ
blood flow rate, and interstitial vol… Show more
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