A Population of Murine γδ T Cells That Recognize an Inducible MHC Class Ib Molecule

Abstract

Although gammadelta T cells are implicated in regulating immune responses, gammadelta T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the gammadelta T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory gammadelta T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gammadelta T cell activation.

MHC class I-dependent Vγ4+pulmonary T cells regulate αβ T cell-independent airway responsiveness

“…This finding is consistent with other recent studies associating TCR-defined subsets of ␥␦ T cells with distinct functional roles (23,(25)(26)(27)(28). The requirement for a TCR-defined population also suggests that TCR-ligand recognition and the particular specific ligand of the regulatory ␥␦ T cell subset are important in maintaining normal airway function (29).…”

Influenza Virus Infection Causes Global Respiratory Tract B Cell Response Modulation via Innate Immune Signals

“…5B). T10 and T22 are two closely homologous nonclassical MHC molecules that act as ligands for roughly 0.5% of all ␥␦ T cells in many inbred mouse strains (33). Increased expression of these nonclassical MHC molecules was not due simply to an up-regulation of all MHCI like molecules caused by increased ␤ 2 -microglobulin expression (Table I).…”

Peptide-Independent Folding and CD8αα Binding by the Nonclassical Class I Molecule, Thymic Leukemia Antigen

“…Thermal denaturation studies have been performed with one additional nonclassical class I molecule, T10 (40). T10 and the closely related T22 (94% identity) are recognized by a subpopulation of ␥␦ T cells in mice without a requirement for bound peptide or other components (40,43). The crystal structure of T22 demonstrates a severely modified FIGURE 4.…”