A population level analysis of second hematological malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma survivors in the era of targeted therapies
Abstract:With improvement in survival after chronic lymphocytic leukemia (CLL) diagnosis, the real‐world burden of second hematological malignancies (SHM) has not been comprehensively assessed in recent era. We analyzed risk, incidence, and outcomes of SHM in CLL patients between 2000 and 2019 using SEER database. CLL patients had greater risk for hematological malignancies than general population [SIR, standardized incidence ratio (95% CI):2.58 (2.46–2.70); p < 0.05]. The risk for subsequent lymphoma increased by 1… Show more
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