A population-based study of the association between betel-quid chewing and the metabolic syndrome in men

Liu

et al. 2009

Public Health Nutr.

Background: Betel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men. Methods: We retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1?73 m

Section: Discussionmentioning

confidence: 99%

Association between betel-nut chewing and chronic kidney disease in men

Liu

et al. 2009

Public Health Nutr.

Cancer Prevention Research

“…For instance, among the adult male population in Taiwan, 46% drink alcohol, 15% chew betel quid, and 57% smoke cigarettes (3), which are all behaviors that result in an increased incidence of SCC (4). Following a negative endoscopy, an efficient risk-assessment method is needed to design surveillance programs for early detection of superficial SCC in the head and neck region and esophagus (2).…”

Section: Introductionmentioning

confidence: 99%

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

Lee

Wang

et al. 2011

We quantified field cancerization of squamous cell carcinoma in the upper aerodigestive tract with epigenetic markers and evaluated their performance for risk assessment. Methylation levels were analyzed by quantitative methylation-specific PCR of biopsied specimens from a training set of 255 patients and a validation set of 224 patients. We also measured traditional risk factors based on demographics, lifestyle, serology, genetic polymorphisms, and endoscopy. The methylation levels of four markers increased stepwise, with the lowest levels in normal esophageal mucosae from healthy subjects without carcinogen exposure, then normal mucosae from healthy subjects with carcinogen exposure, then normal mucosae from cancer patients, and the highest levels were in cancerous mucosae (P < 0.05). Cumulative exposure to alcohol increased methylation of homeobox A9 in normal mucosae (P < 0.01). Drinkers had higher methylation of ubiquitin carboxyl-terminal esterase L1 and metallothionein 1M (P < 0.05), and users of betel quid had higher methylation of homeobox A9 (P ¼ 0.01). Smokers had increased methylation of all four markers (P < 0.05). Traditional risk factors allowed us to discriminate between patients with and without cancers with 74% sensitivity (95% CI: 67%-81%), 74% specificity (66%-82%), and 80% area under the curve (67%-91%); epigenetic markers in normal esophageal mucosa had values of 74% (69%-79%), 75% (67%-83%), and 83% (79%-87%); and both together had values of 82% (76%-88%), 81% (74%-88%), and 91% (88%-94%). Epigenetic markers done well in the validation set with 80% area under the curve (73%-85%). We concluded that epigenetics could improve the accuracies of risk assessment.

“…Betel-quid chewing has a carcinogenic effect and is associated with obesity, hypertriglyceridemia, hyperglycemia, metabolic syndrome, cardiovascular disease, hepatic dysfunction, cirrhosis of the liver, and liver cancer [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tobacco-Smoking, Alcohol-Drinking, and Betel-Quid-Chewing Behaviors: Development and Use of a Web-Based Survey System (Preprint)

Hsu¹,

Tsai²,

Huang³

et al. 2018

Preprint