A Population-based Study of Prognostic Factors Related to Major Disability in Very Preterm Survivors

Perrott, Sylvia; Dodds, Linda; Vincer, Michael

doi:10.1038/sj.jp.7210867

Cited by 15 publications

(11 citation statements)

References 37 publications

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“…Aim: In February of this year, an internal audit was conducted of the compliance with our unit's protocol for oxygen saturation alarms. Our results were in keeping with those described in the literature (1,2), the upper alarm settings were correct in 27%, the lower in 83.6%, and the saturations were within the target range 44% of the time. A teaching phase was then initiated for all staff regarding the audit results and the importance of adherence to the alarms for lowering BPD (3).…”

Section: Referencessupporting

confidence: 93%

“…Near Infrared spectroscopy can be used to assess cerebral blood flow and autoregulation. Aim: (1) To determine a normal reference range for cerebral tissue oxygenation (TOI) using near infrared spectroscopy in premature infants less than 1,500 g, (2) To determine changes in TOI with increasing postnatal age and correlate these with short term outcome (death or ultrasound abnormality). Methods: TOI was measured by spatially resolved spectroscopy (NIRO 200 Hamamatsu) in infants less than 1,500 g for 2 h a day for the first 3 days of life.…”

Section: Referencesmentioning

confidence: 99%

“…Molecular genetic testing is now underway in this cohort of patients. The National Children's Hospital, 2 Microbiology Department, Tallaght Hospital, Dublin 24…”

mentioning

confidence: 99%

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Irish Paediatric Association

2010

Ir J Med Sci

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Section: Referencessupporting

confidence: 93%

Section: Referencesmentioning

confidence: 99%

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Irish Paediatric Association

2010

Ir J Med Sci

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“…Moreover, plasma chloride concentration has also a strong correlation with plasma sodium concentration, and several retrospective investigations focused on natraemia have reported that changes in sodium levels, as well neonatal hyper- or hyponatraemia, were associated to increased risk of severe cerebral haemorrhage and cerebral palsy [2, 20]. …”

Section: Resultsmentioning

confidence: 99%

Chloride Balance in Preterm Infants during the First Week of Life

Iacobelli

Kermorvant‐Duchemin

Bonsante

et al. 2012

International Journal of Pediatrics

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Objective. To describe the chloride balance in infants born 25–32-week gestation, analyze the association of chloride changes with hydroelectrolytic status and their relationship with perinatal conditions, morbidities, and neurological outcome. Methods. For 7 days after birth, sodium and chloride balance, plasma potassium, phosphate, and total carbon dioxide (tCO2) were prospectively determined and strong ion difference (SID) calculated. Three multivariate regression analyses were performed to identify factors associated with high plasma chloride concentration, low SID, and low tCO2. Results. 107 infants were studied. Plasma chloride concentration was significantly positively associated with plasma sodium concentration. Higher plasma chloride and lower SID were significantly associated with lower plasma tCO2. Chloride intake was the main independent factor associated with high plasma chloride, low SID, and low plasma tCO2, with lesser contribution of sodium intake and low gestational age (GA). Also, patent ductus arteriosus and birth weight loss were independent factors affecting plasma chloride and SID. Neither high chloride levels nor low SID were associated to impaired neurological outcome. Conclusions. In preterm infants, chloride balance is influenced by GA and by interrelationship between sodium and chloride intake. High chloride levels are associated with metabolic acidosis but not related to increased risk of impaired neurological outcome.

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“…Lupton et al [9] reported no increase in intraventricular hemorrhage related to maximum sodium levels between 152 and 160 mmol/l, whereas Perrott et al [10] found that hypernatremia is associated with the development of major disability in infants between 22 and 30 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

Severe Hypernatremia in an Extremely Low Birth Weight Infant with Subsequent Normal Neurological Development

Sabir

Stannigel²,

Mayatepek³

et al. 2009

Neonatology

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Severe preterm hypernatremia is a life-threatening electrolyte disorder which mainly causes neurological complications such as brain edema, intracranial hemorrhages, hemorrhagic infarctions and thromboses. We report the case of an extremely low birth weight infant (520 g, 24+6 weeks of gestation) with severe hypernatremia of 199 mmol/l due to a failure in the preparation of an infusion on the 7th day of life. The infant subsequently showed no signs of central nervous system complications and no neurological symptoms due to this mishap so far. MRI scan performed after 4 months showed no evidence of cerebral complications including white matter injury. Even severe hypernatremia might not inevitably lead to central nervous system dysfunction and seizures in extremely low birth weight infants.

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A Population-based Study of Prognostic Factors Related to Major Disability in Very Preterm Survivors

Abstract: This study confirms the association between cystic PVL and major disability observed in other studies. Surgery and hypernatremia will be important to verify in future studies since preventive measures may be possible.

Cited by 15 publications

References 37 publications

Irish Paediatric Association

Irish Paediatric Association

Chloride Balance in Preterm Infants during the First Week of Life

Severe Hypernatremia in an Extremely Low Birth Weight Infant with Subsequent Normal Neurological Development

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