A population-based study of mortality in essential tremor

Louis, Elan D.; Benito‐León, Julián; Ottman, Ruth; Bermejo‐Pareja, Félix

doi:10.1212/01.wnl.0000279339.87987.d7

Cited by 90 publications

(97 citation statements)

References 38 publications

(53 reference statements)

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“…To address this question, we utilized data from the Neurological Disorders in Central Spain (NEDICES) Study, in which participants were followed for a median of 12.5 years, after which the death certificates of those who died were examined. [10][11][12][13][14][15][16][17][18][19][20] METHODS Study population. Data were derived from the NEDICES Study, a longitudinal, population-based survey of the epidemiology of major age-associated conditions of the elderly, including Parkinson disease, essential tremor, stroke, and dementia.…”

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confidence: 99%

“…Data were derived from the NEDICES Study, a longitudinal, population-based survey of the epidemiology of major age-associated conditions of the elderly, including Parkinson disease, essential tremor, stroke, and dementia. [10][11][12][13][14][15][16][17][18][19][20] A detailed account of the NEDICES study population and sampling methods has been published. [21][22][23] The survey area consisted of 3 communities: (1) Las Margaritas (approximately 14,800 inhabitants), a working-class neighborhood in Getafe (Greater Madrid); (2) Lista (approximately 150,000 inhabitants), a professional-class neighborhood in the Salamanca district (Central Madrid); and (3) Arévalo (approximately 9,000 inhabitants), an agricultural zone of Arévalo County (located 125 km northwest of Madrid).…”

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Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

et al. 2014

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Objective: To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality. Methods:In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: #5 hours (short sleepers), 6-8 hours (reference category), and $9 hours (long sleepers). Communitydwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined.Results: A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers 5 1.58, p 5 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p 5 0.03).Conclusions: Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.

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Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

et al. 2014

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“…Furthermore, if at follow-up, we had mis-classified some mild ET cases as controls, this misclassification would have biased our results towards the null hypothesis as it would have made it more difficult to detect true case-control differences. A second issue is that although the criteria for ET we used in this study were identical to those we have used in our previous studies, 20,21,23,24,36 there is the possibility that some of our ET cases were misdiagnosed and that they actually had PD rather than ET. However, a complete UPDRS motor examination was conducted specifically to assess subtle motor features of parkinsonism; none of our ET cases had tremor at rest or other features of parkinsonism on these examinations and none was taking medication for PD (levodopacarbidopa, dopamine agonists or anticholinergic medications).…”

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confidence: 99%

Population-based prospective study of cigarette smoking and risk of incident essential tremor

Louis¹,

Benito‐León²,

Bermejo‐Pareja³

2008

Neurology

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“…Hence descriptions span a broad range and include the statement that it is ‘not progressive’4 and the conflicting statement that it is ‘progressive’,5–7 as well as a full range of statements in between (‘generally mild and non-progressive’,8 ‘may be a progressive neurological disorder’,9 ‘often progressive’,10 ‘usually slowly progressive’11 and ‘slowly progressive’12 13). …”

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confidence: 99%

Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases

Louis

Agnew

Gillman

et al. 2011

Journal of Neurology, Neurosurgery & Psychiatry

107

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Background Despite its high prevalence, there are surprisingly few prospective, longitudinal data on the clinical course of essential tremor (ET). Patients themselves often want to know from their treating physician whether and by how much their tremor is expected to worsen over time. Methods As part of two research protocols, prospective, longitudinal data were collected on tremor severity in two samples of ET cases (44+39 cases, combined n=83). At a baseline and one follow-up evaluation, a detailed clinical assessment was performed and action tremor in the arms was rated by a senior movement disorders neurologist using a standardised clinical rating scale (Total Tremor Score (TTS), range 0–36). Results In the first case sample, TTS increased annually by 0.32±0.89 points (ie, an annual increase of 5.3±17.1% (median 1.8%) from the mean baseline score). TTS increased by ≥0.5 points in 23/24 (95.8%) cases followed for ≥5 years. In the second sample, TTS score increased annually by 0.64±1.49 points (annual increase of 3.1±8.1% (median 2.0%) from the mean baseline score). TTS increased by ≥0.5 points in 11/15 (73.3%) cases followed for ≥5 years. No baseline factors were identified that predicted annual change in TTS. Conclusions Most ET cases exhibited a progressive worsening in tremor scores with time such that the average annual increase in tremor severity from baseline was estimated to be between 3.1% and 5.3% and the median annual increase from baseline was between 1.8% and 2.0%. These published estimates will hopefully be a useful prognostic guide for clinicians and their patients.

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A population-based study of mortality in essential tremor

Abstract: In this longitudinal, prospective study, the risk of mortality was increased in essential tremor. Additional studies of incident cases are needed to confirm these results.

Cited by 90 publications

References 38 publications

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Population-based prospective study of cigarette smoking and risk of incident essential tremor

Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases

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