A population-based study of fatigue and sleep difficulties in inflammatory bowel disease

Abstract

Background: There has been little investigation of fatigue, a common symptom in IBD. The

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

“…However, in the context of IBD, the relationship between iron deficiency and fatigue was not evident in our study. Perhaps in the presence of chronic disease, whether active or in remission, other processes related to stress or sleep disturbances may play a greater contributory role with fatigue in IBD than measurable iron levels (8). It should be noted that iron sequestration, and thus possibly iron deficiency in the setting of prolonged chronic illness, is a genetic determined adaptive response to sickness (48).…”

“…(2)(3)(4)(5)(6). It is also quite prevalent in inflammatory bowel disease (IBD) (7)(8)(9)(10)(11) and has been shown to adversely affect quality of life (9). In population-based samples of individuals with IBD in Canada (8) and the Netherlands (9), problematic fatigue was reported by over two-thirds of those with active disease [70% (8); 76% (9)], and by 30% (8) and 37% (9) with inactive disease.…”

“…It is also quite prevalent in inflammatory bowel disease (IBD) (7)(8)(9)(10)(11) and has been shown to adversely affect quality of life (9). In population-based samples of individuals with IBD in Canada (8) and the Netherlands (9), problematic fatigue was reported by over two-thirds of those with active disease [70% (8); 76% (9)], and by 30% (8) and 37% (9) with inactive disease. Fatigue is not only one of the most common IBD symptoms reported, along with abdominal pain and diarrhea (7), it is also one of IBD patients' most predominant concerns (12).…”

“…Fatigue may result from a complex interaction of multiple factors including ongoing systemic inflammation, lack of restorative sleep, chronic pain, and psychological distress (6), all of which have been linked to fatigue in IBD (5,8). Anemia has often been assumed to be a primary causal factor of fatigue.…”

Utmattelse ved inflammatorisk tarmsykdom

“…I fire studier (9,10,13,28) hadde man vurdert depresjon i forhold til fatigue, og i alle var det en signifikant positiv assosiasjon. Andre undersøkte faktorer var tett knyttet opp mot depresjon, slik som sykdomsrelaterte bekymringer, angst, stress og psykososiale forhold (13,15,19,21,34).…”