A population-based study of craniosynostosis

French, L. R.; Jackson, Ian T.; Melton, L. Joseph

doi:10.1016/0895-4356(90)90058-w

Cited by 124 publications

(77 citation statements)

References 8 publications

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“…The birth prevalence of craniosynostosis reported in this study, 4.3 per 10,000 live births, is generally consistent with previous estimates of 3.1-4.8 per 10,000 live births [French et al, 1990;Lajeunie et al, 1995;Cohen, 2000]. The overall decline in the birth prevalence of craniosynostosis during the study period appears to be largely attributable to a considerable decrease in the prevalence of lambdoid synostosis.…”

Section: Discussionsupporting

confidence: 91%

“…Craniosynostosis has been reported as a clinical feature in more than 100 genetic syndromes, the most common of which include Apert, SaethreChotzen, and Crouzon syndromes [Cohen, 2000;Katzen and McCarthy, 2000;Muenke and Wilkie, 2001;Kabbani and Raghuveer, 2004]. Although few population-based estimates of the birth prevalence of craniosynostosis are available, estimates from three of these studies range from 3.1 to 4.8 cases per 10,000 live births [French et al, 1990;Lajeunie et al, 1995;Cohen, 2000].…”

Section: Introductionmentioning

confidence: 95%

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A population‐based study of craniosynostosis in metropolitan Atlanta, 1989–2003

Boulet

Rasmussen

Honein

2008

American J of Med Genetics Pt A

305

253

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Craniosynostosis is a birth defect characterized by premature fusion of one or more cranial sutures. We describe the birth prevalence of craniosynostosis and related risk factors among infants born to residents of metropolitan Atlanta during 1989-2003. Data from the Metropolitan Atlanta Congenital Defects Program (MACDP) were used to identify infants with craniosynostosis. Case records with a code for craniosynostosis were reviewed to substantiate the diagnosis of craniosynostosis and to classify infants as having isolated craniosynostosis (no other unrelated major defects), multiple defects (one or more additional major, unrelated defects), or a syndrome (recognized or strongly suspected single-gene condition or chromosome abnormality). Vital records data on births of Georgia residents were used to analyze craniosynostosis prevalence by year of birth, maternal race and age, parity, plurality, and infants' sex, birth weight, and gestational age. We identified 281 infants born with craniosynostosis in metropolitan Atlanta during 1989-2003: 84% with isolated craniosynostosis, 7% with multiple defects, and 9% with syndromes. The birth prevalence was 4.3 per 10,000 births, results consistent with findings from other population-based studies using similar case definitions. Apert syndrome was diagnosed in 40% of the syndromic cases, and sagittal synostosis was diagnosed in 39% of the cases of nonsyndromic craniosynostosis. Maternal age 35 years or older, multiple birth, male sex, and birth weight >4,000 g were risk factors for craniosynostosis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 95%

A population‐based study of craniosynostosis in metropolitan Atlanta, 1989–2003

Boulet

Rasmussen

Honein

2008

American J of Med Genetics Pt A

305

253

View full text Add to dashboard Cite

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“…In addition, some craniosynostoses are not evident after agerelated suture closure had already begun. Population frequencies of craniosynostosis are very low, ranging from 3-15 per 10,000 individuals (Cohen, 1986c;French et al, 1990) although these frequencies tend to be slightly higher in skeletal populations (Bennett, 1967). Thus, control for age in the craniosynostotic group was relaxed to maximize sample size.…”

Section: Methodsmentioning

confidence: 98%

Comparative endocranial vascular changes due to craniosynostosis and artificial cranial deformation

O’Loughlin

1996

Am. J. Phys. Anthropol.

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The processes of craniosynostosis (premature fusion of one or more of the calvarial sutures) and artificial cranial deformation are similar since both can alter the shape of the craniofacial complex. Most research exploring these processes has focused on the ectocranium, although it is obvious that these processes also modify the endocranium. Endocranial changes due to either craniosynostosis or artificial cranial deformation have not been as thoroughly examined. Silicone rubber endocasts were made from 11 craniosynostotic archaeologically derived specimens from North and South America. For comparative purposes, endocasts were made from 22 normal and 17 occipitally deformed crania that were archaeologically derived from North and South America. With all samples, middle meningeal vessel patterns and venous sinus impressions were qualitatively and quantitatively analyzed. Depth, width, and convolution of the middle meningeal vessels were recorded, and the direction of vessel branches was noted. Both artificial cranial deformation and craniosynostosis altered the endocranial vasculature. Middle meningeal vessel and venous sinus impressions of the craniosynostotic group differed when compared to both the undeformed and artificially cranially deformed samples. Sinuses traversing under synostosed sutures became wider and deeper. In contrast, sinuses directly underneath the greatest artificial deformational stress were shallower, while there was compensatory enlargement of sinuses further away from the greatest deformational effects. Such compensatory enlargement also was shown by the high incidence of enlarged occipital/marginal sinuses in artificially deformed skulls. Increased intracranial pressure is hypothesized to be the cause of the venous sinus changes found in craniosynostotic individuals. Middle meningeal vessel patterns from craniosynostotic and artificially deformed specimens were similar in that their direction paralleled the direction of altered cranial growth. These findings demonstrate that the endocranial vasculature is developmentally plastic and responds to deformation in a predictable pattern.

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“…The incidence of nonsyndromic craniosynostosis is approximately 1 in 2500, 1,2 generating approximately 200-240 cases per year in England and Wales. Usually diagnosed at birth, the underlying aetiology is of premature fusion of one or more of the cranial sutures.…”

Section: Nonsyndromic Craniosynostosesmentioning

confidence: 99%

Craniofacial surgery for orbital malformations

Richardson

Thiruchelvam

2006

Eye

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Paediatric craniofacial surgery is a highly specialised field requiring a multidisciplinary team input. Orbital and ocular involvement is relatively common in craniofacial patients. This is more in syndromic patients. In nonsyndromic patients, orbital involvement is common in frontal plagiocephaly and trigonocephaly. The management of these conditions requires close working between the craniofacial surgeon and ophthalmologist. An outline of the management of these deformities is discussed.

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A population-based study of craniosynostosis

Cited by 124 publications

References 8 publications

A population‐based study of craniosynostosis in metropolitan Atlanta, 1989–2003

A population‐based study of craniosynostosis in metropolitan Atlanta, 1989–2003

Comparative endocranial vascular changes due to craniosynostosis and artificial cranial deformation

Craniofacial surgery for orbital malformations

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