A population-based prospective study of optic neuritis

Soelberg, Kerstin; Jarius, Sven; Skejoe, Hanne Pernille Bro; Engberg, Henriette; Mehlsen, Jesper; Nilsson, Anne; Madsen, Jonna Skov; Reindl, Markus; Wildemann, Brigitte; Grauslund, Jakob; Kyvik, Kirsten Ohm; Smith, Terry J.; Lillevang, S T; Paul, Friedemann; Weinshenker, Brian G.; Asgari, Nasrin

doi:10.1177/1352458517734070

Cited by 80 publications

(73 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 All participants had a clinical diagnosis of ON based on the criteria described by the Optic Neuritis Study Group. 13,15 OCT raised suspicion of central serous chorioretinopathy (CSCR) in one 39-year-old male patient 10 days after initial presentation. However, a de novo diagnosis of MS or NMOSD resulting from the qualifying ON event was explicitly allowed.…”

Section: Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Optical coherence tomography in acute optic neuritis: A population-based study

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Patientsmentioning

confidence: 99%

“…13 Here, we report structural damage caused by ON, as quantified by OCT, from this population-based study. 13 Here, we report structural damage caused by ON, as quantified by OCT, from this population-based study.…”

Section: Introductionmentioning

confidence: 98%

Optical coherence tomography in acute optic neuritis: A population-based study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The present study is nicely in line with another recent Danish population‐based prospective study, in which 51 patients with acute ON were identified during a 2‐year period in the Region of Southern Denmark (population: almost 1 million citizens) (Soelberg et al., 2017). Therefore, with the identification of 49 patients with acute ON in the current study, the procedure for referral of patients with ON can be considered to have been nearly complete.…”

Section: Discussionmentioning

confidence: 99%

“…The two Danish studies are also comparable when it comes to gender and age distribution. Furthermore, a similar number of patients were diagnosed with MS during the study period: 18 in the present study vs. 20 in the other study (Soelberg et al., 2017). In addition, no patients were seropositive for anti‐aquaporin‐4 antibodies, but both studies identified antibodies to myelin oligodendrocyte glycoprotein (MOG) in one patient with recurrent/bilateral ON (RON/BON) (Soelberg et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a similar number of patients were diagnosed with MS during the study period: 18 in the present study vs. 20 in the other study (Soelberg et al., 2017). In addition, no patients were seropositive for anti‐aquaporin‐4 antibodies, but both studies identified antibodies to myelin oligodendrocyte glycoprotein (MOG) in one patient with recurrent/bilateral ON (RON/BON) (Soelberg et al., 2017). The presence of anti‐MOG antibodies in patients with RON/BON is also in accordance with other studies (Chalmoukou et al., 2015; Pache et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Time to steroid treatment in severe acute optic neuritis

et al. 2018

View full text Add to dashboard Cite

ObjectivesSteroid treatment can accelerate visual recovery in patients with optic neuritis (ON), but it is unknown whether the timing of the start of treatment influences the outcome. The main purpose of this observational study was to assess the effect of early onset steroid treatment of ON on visual prognosis and retinal morphology.MethodsForty‐nine patients with acute mild/moderate (n = 21) or severe (n = 28) ON, and an equal number of healthy controls were enrolled. Patients with severe ON either received early onset steroid treatment (initiated within 1 week of presentation with visual loss) (n = 9), late‐onset treatment (initiated after 1 week) (n = 13), or no treatment (n = 6). Visual function and retinal morphology was studied after 6 and 12 months.ResultsAll measures of visual function had improved after 6 months (p ≤ 0.03) in the three groups with severe ON. This was not the case for Rayleigh match setting range (SR) in the nontreated group (p = 0.24), or for SR (p = 0.08) and latency to P100 of visual evoked potential (p = 0.08) in the late‐onset treated group. After 12 months, further improvement occurred in the nontreated and late‐treated groups, but not in the early treated group. Macular retinal nerve fiber layer (mRNFL) and ganglion cell plus inner plexiform layer had decreased significantly (p ≤ 0.001) in all three groups with severe ON after 6 months. After 12 months, only mRNFL had further significantly decreased and only in the late‐onset treated group (p = 0.02).ConclusionThe beneficial effects of early onset steroid treatment of ON is limited to a few months whereas the long‐term prognosis is independent of the timing of treatment.

show abstract

Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Cobo‐Calvo

Ruiz

Rollot

et al. 2020

Annals of Neurology

159

171

View full text Add to dashboard Cite

Objective The main objective was to compare clinical features, disease course, and myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) dynamics between children and adults with MOG‐Ab–associated disease (MOGAD). Methods This retrospective multicentric, national study included 98 children and 268 adults with MOGAD between January 2014 and September 2019. Cox regression model for recurrent time‐to‐event data and Kaplan–Meier curves for time to antibody negativity were performed for the objectives. Results Isolated optic neuritis was the most frequent clinical presentation in both children (40.8%) and adults (55.9%, p = 0.013), and acute disseminated encephalomyelitis syndrome was more frequent in children (36.7% vs 5.6%, p < 0.001). Compared to adults, children displayed better recovery (Expanded Disability Status Scale ≥ 3.0 at last follow‐up reached only by 10 of 97 [10.3%] vs 66/247 [26.7%], p < 0.001). In the multivariate analysis, adults were at higher risk of relapse than children (hazard ratio = 1.41, 95% confidence interval [CI] = 1.12–1.78, p = 0.003). At 2 years, 64.2% (95% CI = 40.9–86.5) of nonrelapsing children became MOG‐Ab negative compared to 14.1% (95% CI = 4.7–38.3) of relapsing children (log‐rank p < 0.001), with no differences observed in adults (log‐rank p = 0.280). Interpretation MOGAD patients differ in the clinical presentation at onset, showing an age‐related shift in the clinical features across age groups. Compared to children, adults have a higher risk of relapse and worse functional recovery. Finally, children with monophasic disease become MOG‐Ab negative earlier than relapsing children, but this is not true in adults. Considering these differences, management and treatment guidelines should be considered independently in children and adults. ANN NEUROL 2021;89:30–41

show abstract

A population-based prospective study of optic neuritis

Abstract: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

Cited by 80 publications

References 35 publications

Optical coherence tomography in acute optic neuritis: A population-based study

Optical coherence tomography in acute optic neuritis: A population-based study

Time to steroid treatment in severe acute optic neuritis

Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Contact Info

Product

Resources

About