A population-based epidemiologic study of irritable bowel syndrome in South China: Stratified randomized study by cluster sampling

Xiong, Liang; Chen, Minhu; Chen, Huixin; An, Xiaobo; Wang, Weian; Hu, Pinjin

doi:10.1016/s0016-5085(03)81970-4

Cited by 30 publications

(49 citation statements)

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“…10,11 The incidence of IBS is equal between adults and adolescents but the symptoms of IBS usually start in the early childhood or adolescence. [12][13][14][15] Although IBS is not a life-threatening condition for most patients it is a chronic recurrent illness that is often accompanied by severe impairment in health related quality of life (HRQOL) measures like decrease in concentration, energy, vitality and self-confidence, and increase in absence rates from work stations.…”

Section: Introductionmentioning

confidence: 99%

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

et al. 2017

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Background: Irritable bowel syndrome (IBS) is a common functional disorder throughout the world with no clear diagnostic markers. The diagnosis relies mostly on clinical presentation. In India, IBS is less estimated in lower socioeconomic group population. The objective of this study was to assess the proportions of symptoms compatible with IBS, and its prevalence among the patients of low socio-economic strata.Methods: An OPD based observational study carried out in a tertiary care hospital in south Delhi for a period of 10 years (Nov-2006 to Oct-2016). This hospital caters to low socioeconomic strata. All the study subjects were interviewed based on questionnaires compatible with Manning and Rome II criteriaResults: Symptoms of IBS was more in male (65.12%) and highest prevalence was in the age group 31 to 35 years (56.62%), flatulence was found to be the most common symptom compatible with IBS (58.37%) followed by pain abdomen (42.9%), loose motion (38.6%) and constipation (30.5%). The other important associated symptoms were headache 47.7% and insomnia in 44.62%.Conclusions: The symptoms compatible with IBS are common among the lower socioeconomic strata leading to a negative impact on their health-related quality of life and work performance, with high rate of physician's visits and further deteriorating their economic condition. Early diagnosis and health education may improve the quality of life and productivity in this population.

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Section: Introductionmentioning

confidence: 99%

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

et al. 2017

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“…There is a paucity of data on IBS among older adults, especially data that provide a direct comparison with the younger patients. Most of the data for older adults come from other countries, whereas either the studies done in the United States did not look at the age-related differences or they studied samples that were skewed, e.g., almost exclusively Caucasians, and as such did not represent the population at large (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). The significance of the sociodemography of a disease and its impact on QOL may be different for persons living in almost exclusively one-race areas versus those living in multiethnic localities.…”

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confidence: 99%

Prevalence, Sociodemography, and QualitLife of Older Versus Younger Patients with Irritable Bowel Syndrome: A Population-Based Study

et al. 2006

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We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL compared to younger IBS patients. A total of 1000 adults from nine sites, including a medical center, churches, and a blood bank in our metropolitan area (670 African Americans, 320 Caucasians, and 10 others), completed self-administered questionnaires providing sociodemographic information and details regarding bowel habits and associated symptoms for diagnosing the IBS based on Rome II criteria. QOL was assessed by the SF-12 questionnaire. The study database was divided into two groups, younger (< 50 years) and older (> or = 50 years). The two age groups were similar with respect to gender and household income. Ninety-five of the 1000 participants had IBS, giving a total sample prevalence of 9.5% (< 50 years, 9.9%, vs > or = 50 years, 7.6%). The prevalence of IBS was similar in the two groups irrespective of race, sex, marital status, size of household, location of residence (rural versus urban), level of educational status, and household income. Compared to the older group, there was a trend toward a higher prevalence of IBS among divorced subjects (12.7% vs 0%; P = 0.1) and those below poverty level of income (15.3% vs 7.5%; P = 0.09) in the younger subjects. In contrast, older IBS patients were more likely to attend church regularly (32.5% vs 58.8%; P < 0.05). There were no differences in history of traveler's diarrhea, food intolerance, and drug allergies between the two groups. Health care utilization was similar between the two IBS groups in terms of number of physician visits, use of prescription and alternative medications, and being disabled due to IBS. There was no difference in the overall QOL score means (27.8 vs 29.5; P = NS) or in its general health and physical functioning components. However, older IBS patients had better social functioning (9.1 vs 9.8; P < 0.05). Although in our study IBS occurred less frequently among older adults than among younger patients, the difference is not statistically significant. While IBS affects QOL at all ages, social functioning was actually better on average among older compared to younger IBS patients.

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“…The prevalence of IBS in Asia is reportedly 5-9% [2][3][4][5][6][7][8][9][10][11][12][13], while in Western countries it is 10-20% [14][15][16][17][18][19][20][21][22][23][24][25]. Furthermore, no female predominance was found in Asian IBS patients [2], in contrast to in Western IBS patients [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…Abdominal bloating is a more common complaint than pain in Asians, and this abdominal pain is localized to the upper abdomen rather than in the lower abdomen like it is in Western patients. Moreover, alteration in bowel habits is much less prominent in Asian IBS patients than in Western patients [2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Chromogranin A cell density in the large intestine of Asian and European patients with irritable bowel syndrome

Patcharatrakul

Hatlebakk

Hausken

et al. 2017

Scandinavian Journal of Gastroenterology

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Objective: Patients with irritable bowel syndrome (IBS) in Asia show distinctive differences from those in the western world. The gastrointestinal endocrine cells appear to play an important role in the pathophysiology of IBS. The present study aimed at studying the density of chromogranin A (CgA) cells in the large intestine of Thai and Norwegian IBS patients. Methods: Thirty Thai IBS patients and 20 control subjects, and 47 Norwegian IBS patients and 20 control subjects were included. A standard colonoscopy was performed in both the patients and controls, and biopsy samples were taken from the colon and the rectum. The biopsy samples were stained with hematoxylin-eosin and immunostained for CgA. The density of CgA cells was determined by computerized image analysis. Results: In the colon and rectum, the CgA cell densities were far higher in both IBS and healthy Thai subjects than in Norwegians. The colonic CgA cell density was lower in Norwegian IBS patients than in controls, but did not differ between Thai IBS patients and controls. In the rectum, the CgA cell densities in both Thai and Norwegian patients did not differ from those of controls. Conclusions: The higher densities of CgA cells in Thai subjects than Norwegians may be explained by a higher exposure to infections at childhood and the development of a broad immune tolerance, by differences in the intestinal microbiota, and/or differing diet habits. The normal CgA cell density in Thai IBS patients in contrast to that of Norwegians may be due to differences in pathophysiology.ARTICLE HISTORY

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A population-based epidemiologic study of irritable bowel syndrome in South China: Stratified randomized study by cluster sampling

Cited by 30 publications

References 0 publications

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

Assessment of IBS symptoms among patients of lower socio-economic strata attending medicine OPD in a tertiary care hospital in South Delhi

Prevalence, Sociodemography, and QualitLife of Older Versus Younger Patients with Irritable Bowel Syndrome: A Population-Based Study

Chromogranin A cell density in the large intestine of Asian and European patients with irritable bowel syndrome

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