A population-based comparison between actual maternal weight gain and the Institute of Medicine weight gain recommendations in singleton pregnancies

Tul, Nataša; Bregar, Andreja Trojner; Steblovnik, Lili; Verdenik, Ivan; Lučovnik, Miha; Blickstein, Isaac

doi:10.1515/jpm-2014-0386

Cited by 5 publications

(6 citation statements)

References 4 publications

(5 reference statements)

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“…We report that women with PCOS have higher GWG, which is consistent with prior reports of higher longitudinal weight gain in PCOS . Our findings here of higher BMI and GWG in PCOS is supported by prior findings in the general population of higher GWG being associated with higher baseline BMI . For women with PCOS, these may be related to abnormal appetite regulation, energy expenditure, psychological function, and higher energy intake .…”

Section: Discussionsupporting

confidence: 91%

“…These are potential important confounding factors in regard to infant outcomes in PCOS as both obesity and longitudinal weight gain are more prevalent in women with PCOS. Women with a higher body mass index (BMI) have higher rates of exceeding recommended GWG . However, the limited research examining GWG in PCOS shows conflicting results with either similar or higher GWG for women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

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The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression

et al. 2019

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Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. The meta-analyses included 42 studies in 7041 women with PCOS and 63 722 women without PCOS.PCOS was associated with higher gestational weight gain (GWG) and with higher preterm birth and large for gestational age and with lower birth weight with this association varying by geographic continent, PCOS phenotypes, and study quality.However, PCOS was associated with none of these outcomes on BMI-matched studies. Gestational diabetes was significantly associated with an increased preterm birth on meta-regression. We report for the first time that GWG is higher in PCOS.Infant outcomes vary by geographic continent and study quality but are similar in BMI-matched women with and without PCOS. This suggests that infant outcomes in PCOS may be related to maternal obesity. These novel findings warrant future studies in PCOS investigating screening and management of infant outcomes with consideration of maternal obesity.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression

et al. 2019

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“…The prevalence of gestational diabetes mellitus (GDM) is steadily increasing worldwide [1,2]. GDM, defined as any degree of glucose intolerance of variable severity with onset or first recognition occurring during pregnancy [3], is a common complication of pregnancy and affects 5%-9% of pregnant women [3,4]. Pre-pregnancy body mass index (BMI) is a known significant risk factor of GDM, and it is highly associated with several adverse pregnancy outcomes, including large for gestational Ivyspring International Publisher age (LGA), preeclampsia, and cesarean delivery [1,5].…”

Section: Introductionmentioning

confidence: 99%

Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers

et al. 2021

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Background: Macrosomic birth weight has been implicated as a significant risk factor for developing various adult metabolic diseases such as diabetes mellitus and coronary heart diseases; it has also been associated with higher incidences of complicated births. This study aimed to examine the predictability of macrosomic births in hyperglycemic pregnant women using maternal clinical characteristics and serum biomarkers of aneuploidy screening performed in the first half of pregnancy. Methods: A retrospective observational study was performed on a cohort of 1,668 pregnant women who 1) had positive outcomes after undergoing 50-g oral glucose challenge test (OGCT) at two university-based hospitals and 2) underwent any one of the following maternal biomarker screening tests for fetal aneuploidy: triple test, quadruple test, and integrated test. Logistic regression-based models for predicting macrosomic births using maternal characteristics and serum biomarkers were developed and evaluated for prediction power. A nomogram, which is a graphical display of the best predictable model, was then generated. Results: The study cohort included 157 macrosomic birth cases defined as birth weight ≥3,820 g, which was equivalent to the top 10 percentile of the modeling cohort. Three primary models solely based on serum biomarkers achieved area under curves (AUCs) of 0.55-0.62. Expanded models, including maternal demographic and clinical factors, demonstrated an improved performance by 25% (AUCs, 0.69-0.73). Conclusion:Our prediction models will help to identify pregnancies with an elevated risk of macrosomic births in hyperglycemic mothers using maternal clinical factors and serum markers from routine antenatal screening tests. Prediction of macrosomic birth at mid-pregnancy may allow customized antenatal care to reduce the risk of macrosomic births.

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“…These criteria, however helpful, do not seem realistic for a significant proportion of pregnant women [8] . With these in mind, we sought to focus on the effect of being underweight before pregnancy on pregnancy outcome and to evaluate perinatal advantages and disadvantages by using a large population-based dataset.…”

Section: Introductionmentioning

confidence: 99%

Perinatal Advantages and Disadvantages of Being Underweight before Pregnancy: A Population-Based Study

Bregar

Blickstein

Šimenc

et al. 2016

Gynecol Obstet Invest

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Aims: To evaluate the advantages and disadvantages of being underweight before pregnancy. Methods: Cohort study of a large population-based dataset of singleton births was used to compare maternal and neonatal outcomes of pre-gravid underweight body mass index (BMI <18.5 kg/m²) women with pre-gravid normal weight controls (BMI 18.5-24.9 kg/m²). Results: A total of 10,995 pre-gravid underweight and 146,155 pre-gravid normal weight mothers were compared. The mean maternal age and gestational age were not different but lean mothers were significantly and more frequently primiparous, had a higher incidence of births at <36 and <32 weeks' gestation, and had a significantly higher incidence of low and very low birth weight infants. Lean mothers had a significantly lower incidence of birth weights >4,000 g, less cesarean births and a lower incidence of gestational diabetes and hypertensive disorders. Conclusions: A tradeoff exists between the advantages of being lean before pregnancy in terms of less maternal morbidity in return for gaining a more advanced gestational age and higher birth weight.

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A population-based comparison between actual maternal weight gain and the Institute of Medicine weight gain recommendations in singleton pregnancies

Cited by 5 publications

References 4 publications

The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression

The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression

Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers

Perinatal Advantages and Disadvantages of Being Underweight before Pregnancy: A Population-Based Study

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