A population-based case-control study to evaluate the role of codon 164 of beta 2-adrenergic receptor gene polymorphism in Iranian PCOS patients

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder. This syndrome is a genetic disorder that involves about 5 to 10 percent of women in reproductive age. The purpose of this study was to investigate the effect of codon 164 of beta-2 adrenergic receptor (NM-_000024.5:c.491C>T) polymorphism in patients with PCOS. The normal form of this codon is ACC and when polymorphism 112 Shahla Lotfi et al. occurs, it changes to the ADRB2rs1800888 (Thr164Ile) with codon ATC. This case-control study consisted of 14 Iranian patients (mean age 26.86±1.03), along with 13 healthy controls, from Infertility Center of Valie Asre, Imam Khomaini Hospital Complex in May 2013 until Feb 2014. Data analysis was done by statistical software SPSS, version 19.0. The result shows that, two persons of control group and one individual of patient group had polymorphism codon 164. The P-value greater than 0.05 (P>0.05) demonstrated that there is no correlation between Thr164Ile polymorphism and PCOS.