A Polyplex in a Shell: The Effect of Poly(aspartic acid)-Mediated Calcium Carbonate Mineralization on Polyplexes Properties and Transfection Efficiency
Abstract:Mineralization by exposure of organic
templates to supersaturated
solutions is used by many living organisms to generate specialized
materials to perform structural or protective functions. Similarly,
it was suggested that improved robustness acquired through mineralization
under natural conditions could be an important factor for virus survival
outside of a host for better transfection of cells. Here, inspired
by this fact, we developed a nonviral tricomponent polyplex system
for gene delivery capable of unde… Show more
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