A polymorphism of the methylenetetrahydrofolate reductase and methionine synthase gene in CAD patients: association with plasma folate, vitamin B12 and homocysteine

Vitamin B12 Status in Males and Females of different Age Groups

“…These results suggest that Jordanians eat adequate animal products to increase the daily intake of vitamin B12. However, it is possible that there may be other important factors like geographical variation (Bindra et al, 1987), different life style (Papandreou et al, 2006), racial and ethnic differences (Bindra et al, 1987), genetic factors (Feng et al, 2009;Jang et al, 2002), normal absorption of vitamin B12 (Roddie and Davis, 2009), the storage period of fresh juices (Chandrasekaram et al, 2009), adequate daily intake of vitamin B12 and folic acid (Fenech, 2001), the plasma level of vitamin E and vitamin C (Adewolu and Aro, 2009;Madhavi et al, 2009) as well as the accurate cooking of vegetables (Rowe et al, 2009) and folic acid supplementation of grain products (Roddie and Davis, 2009), that were not taken in consideration in this study that could influence the vitamin B12 status of subjects.…”

“…It would also be interesting to evaluate the vitamin B12 content of complete meals, hospital diet, as well as food from animal sources since there is no information available concerning these items. Since it is emerging that genetic factors influence vitamin B12 metabolism (Feng et al, 2009;Jang et al, 2002), it would be useful to complement such studies with an analysis of relevant genetic polymorphisms. Furthermore, it would be interesting to establish whether genetic variations in candidate genes in combination with nutritional factors (e.g., vitamin B12 status) are associated with susceptibility to common disease.…”

“…The main causes of vitamin B12 deficiency include nutritional deficiency, malabsorption syndromes, gastrointestinal causes and rare genetic disorders (Roddie and Davis, 2009;Feng et al, 2009;Jang et al, 2002). Absorption problems due to lack of intrinsic or intestinal factors are thought to be the most common cause of vitamin B12 deficiency (Roddie and Davis, 2009).…”