A polymorphism of the interleukin-1 β gene influences survival in pancreatic cancer

Barber, Matthew D.; Powell, James J.; Lynch, Susan; Fearon, K. C. H.; Ross, James A.

doi:10.1054/bjoc.2000.1479

Cited by 104 publications

(57 citation statements)

References 23 publications

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“…None significant correlation was found with PDAC and IPMN cases. Although Barber et al [36] , reported that the +3954 C/T polymorphism of the IL-1β gene predisposes to pancreatic cancer; our findings did not reveal any significant association. Additionally, they are partly in agreement with the findings of Cigrovski Berkovic et al [37] , which suggest that there is an association between the IL-1β 511 C/T genotype and the susceptibility to pNET, especially functional pNETs.…”

Section: Discussioncontrasting

confidence: 99%

Genetic polymorphisms ofinterleukin 1βgene and sporadic pancreatic neuroendocrine tumors susceptibility

Karakaxas¹,

Sioziou²,

Aravantinos³

et al. 2016

WJGO

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Section: Discussioncontrasting

confidence: 99%

Genetic polymorphisms ofinterleukin 1βgene and sporadic pancreatic neuroendocrine tumors susceptibility

Karakaxas¹,

Sioziou²,

Aravantinos³

et al. 2016

WJGO

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“…The distribution of IL-1bþ3953, IL-1b-511 and IL-1RA polymorphism in a control population is presented in Table II, together with Japanese 25,26 and Caucasian 3,7,8,15 data, which have been previously reported. The polymorphism frequency in our study was within the Hardy-Weinberg equilibrium.…”

Section: Polymorphisms Of Il-1b and Il-1ra In The Control Populationmentioning

confidence: 89%

“…4 Barber et al reported that the serum level of IL-1b is higher in the genotype IL-1bþ3953 T/T. 7 Thus, it may be through IL-1b-mediated inflammation and hypochlorhydria that the cancer risk in the gastric corpus is higher in the genotype IL-1bþ3953 C/T in Japanese. The fact seemed to be in contrast to the reports of El-Omar et al, who found no difference in the groups defined by the location of the carcinoma (corpus and antrum).…”

Section: Table III -Frequencies and Adjusted Odds Ratios (Or) Of 1l-1mentioning

confidence: 99%

“…4 C to T base change is observed in exon 5 at position þ3953 (IL-1b 3953). [5][6][7] IL-1b C-511T is found in the promoter region at position -511, which shows nearly complete disequilibrium with IL-1b T-31C. 3,8 The IL-1 receptor antagonist (IL-1RA) gene, encoding an endogenous inhibitor for IL-1b, has a variable number tandem repeat (VNTR) polymorphism, 9 which is also associated with a variety of inflammatory gastrointestinal diseases.…”

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confidence: 99%

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Cancer risk to the gastric corpus in Japanese, its correlation withinterleukin‐1βgene polymorphism (+3953*T) and Epstein‐Barr virus infection

Sakuma

Uozaki

Chong

et al. 2005

Intl Journal of Cancer

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Polymorphisms of interleukin-1 (IL-1) genes have been reported to modify the risk of gastric carcinoma (GC) in Caucasians. The significance of IL-1b gene polymorphisms was evaluated in Japanese GC patients with or without infection of Helicobacter pylori and Epstein Barr virus (EBV) with special reference to the topographic features of GC. IL-1b gene polymorphisms at positions -511 and +3953 were evaluated by PCR-RFLP and a penta-allelic polymorphism of IL-1RA by PCR in healthy controls (n = 103) and GC (n =140; corpus 95, antrum 45). EBV-infection was determined in the neoplastic tissues by EBER1 in situ hybridization, and H. pylori infection in nonneoplastic gastric mucosa by PCR targeting of the H. pylori urease A gene. GC consisted of EBV-associated (n = 24) and EBV-negative (n = 116) patients, whereas H. pylori infection was positive in 130 cases. Among IL-1b gene polymorphisms, genotype IL-1b+3953 C/T was more frequent in the EBV-negative (21%) and corpus GC (23%) patients, compared to the controls (10%), respectively, although there was no genotype IL-1b+3953 T/T in either group. Thus, the effect of IL-1b+3953 T was statistically significant in logistic regression models adjusted for age in EBV negativity (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.02-5.05) and in the corpus GC (2.70, 1.19-6.12) with highest OR 3.55 (1.54-8.23) in EBV-negative corpus GC. There was no significant influence of IL-1 gene polymorphism in EBV-associated GC, but it occurred predominantly in the corpus (24/24) compared to EBV-negative GC (71/116) (p = 0.00002). There was no correlation between H. pylori infection and IL-1 gene polymorphism in GC. The cancer risk of the gastric corpus in Japanese is influenced by IL-1b+3953 polymorphisms. On the other hand, the risk of EBV-associated GC, which occurs predominantly in the corpus, is not influenced by this pro-inflammatory polymorphism. ' 2005 Wiley-Liss, Inc.

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“…One recent case-control study in China examined the association between lung cancer and IL1B C3954T (14); although results were negative, the study was limited by low statistical power (n = 119 cases). The IL1B C3954T polymorphism has been associated with risk of cervical dysplasia (32) and mortality after pancreatic cancer diagnosis (33). Some studies also found this polymorphism associated with risk of gastric cancer (34).…”

Section: Discussionmentioning

confidence: 99%

Systematic Evaluation of Genetic Variants in the Inflammation Pathway and Risk of Lung Cancer

et al. 2007

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Inflammatory responses to environmental exposures, such as tobacco smoke, may play a role in lung carcinogenesis. To test this hypothesis, we studied genetic polymorphisms in the inflammation pathway in relation to lung cancer risk. We evaluated a panel of 59 single nucleotide polymorphisms (SNP) in 37 inflammation-related genes among non-Hispanic Caucasian lung cancer cases (N = 1,553) and controls (N = 1,730) from Houston, Texas. Logistic regression was used to assess associations with lung cancer under a dominant genetic model adjusted for sex, age, and smoking. Haplotypes were estimated with the expectation-maximization algorithm. False-positive report probabilities (FPRP) were calculated for significant associations. Interleukin 1B (IL1B) C3954T was associated with lung cancer [odds ratio (OR), 1.27; 95% confidence interval (95% CI), 1.10-1.47; FPRP 0.148]. Two IL1A SNPs (C-889T and Ala 114 Ser) were also related to lung cancer (OR, 1.18-1.22), although FPRPs were higher. One IL1A-IL1B haplotype, containing only the IL1B 3954T allele, was associated with elevated lung cancer risk (OR, 1.80; 95% CI, 1.24-2.61). These associations were stronger in heavy smokers, particularly for IL1B C3954T (OR, 1.59; 95% CI, 1.28-1.97; FPRP 0.004). Lung cancer risk was unrelated to polymorphisms in IL1 receptor or antagonist genes. Associations with lung cancer were also seen for SNPs in granulocyte macrophage colony stimulating factor and peroxisome proliferatoractivated factor-D, but FPRPs were high. IL1A and IL1B polymorphisms are associated with increased lung cancer risk, especially among heavy smokers. IL1A and IL1B are critical signals in initiating inflammation. Our results suggest that a dysregulated inflammatory response to tobaccoinduced lung damage promotes carcinogenesis. [Cancer Res 2007;67(13):6520-7]

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A polymorphism of the interleukin-1 β gene influences survival in pancreatic cancer

Cited by 104 publications

References 23 publications

Genetic polymorphisms ofinterleukin 1βgene and sporadic pancreatic neuroendocrine tumors susceptibility

Genetic polymorphisms ofinterleukin 1βgene and sporadic pancreatic neuroendocrine tumors susceptibility

Cancer risk to the gastric corpus in Japanese, its correlation withinterleukin‐1βgene polymorphism (+3953*T) and Epstein‐Barr virus infection

Systematic Evaluation of Genetic Variants in the Inflammation Pathway and Risk of Lung Cancer

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