A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC of miR-196a (rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56-0.98). Furthermore, a significant association was observed between this genotype and glioma risk in the subgroups of adult glioma (OR = 0.73, 95% CI:0.55-0.98), male glioma (OR = 0.69, 95% CI:0.48-0.99) and patients with glioblastoma (OR = 0.58, 95% CI:0.37-0.91). This was the first study investigating the association between the miR-196a rs11614913 and glioma risk. Compared with the results from previous studies in lung cancer and breast cancer, our data suggest a different genotype association in glioma. This may be related to the diversity on the tissue origin, tumor type, tumorigenesis, and developing process.

miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects

“…During the reading of the 25 full-text manuscripts, 4 studies were excluded due to incomplete rs11614913 polymorphism distribution data required for OR calculation (10)(11)(12)(13). For the remaining 21 records, baseline characteristics of the patients and control subjects were summarized, the study quality was assessed, HWE in particular was assessed by Chi-square test; two records involving Indian populations published in 2011 were excluded for disagreement with HWE (P<0.05) (14,15), thus leaving 19 articles identified with criteria for inclusion and exclusion (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). All studies were case-control studies.…”

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

“…Furthermore, serum levels of miR-196a were significantly increased in patients with pancreatic cancer, and higher serum levels were associated with advanced clinical stage and shorter survival time (Kong et al, 2011). The miR-196a gene polymorphism has also been shown to contribute to cancer risk and susceptibility (Dou et al, 2010;Lee et al, 2014), suggesting it has an oncogenic role during the development of cancer.…”

Genetic and epigenetic factors in regulation of microRNA in colorectal cancers

“…In different studies were highlighted several associations between one or more SNPs of these mRNA and cancers [19][20][21][22].…”