A polymorphism in the promoter region of catalase is associated with blood pressure levels

Jiang, Zhengwen; Akey, Joshua M.; Shi, Jianxin; Xiong, Momiao; Wang, Ying; Shen, Yayun; Xu, Xiaoyun; Chen, Hua; Wu, Hong; Xiao, Junhua; Lu, Daru; Huang, Wei; Li, Jin

doi:10.1007/s004390100553

Cited by 92 publications

(60 citation statements)

References 19 publications

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“…Although smoking did not seem to affect associations, there was modification of relationships by consumption of fruits and vegetables, with catalase activity decreasing with increasing intake, only among those with CT or TT genotypes. These findings support our a priori hypothesis that CT and TT genotypes are associated with lower catalase activity and provide a biological basis for epidemiologic studies showing associations between CAT genotype and risk of diseases related to oxidative stress (13,14,16,20).…”

Section: Discussionsupporting

confidence: 86%

“…with CC genotype, and those with CT genotype had intermediate risk (13). Thus, our findings of genotype/ phenotype relationships support the results from epidemiologic studies, providing a functional basis for the investigation of the À262C !…”

Section: Discussionsupporting

confidence: 86%

“…T substitution at position À262 in the 5 ¶ region (12), which is thought to result in reduced activity. Reduction in catalase activity may play a role in host response to oxidative stress and, indeed, variant CAT T alleles have been associated with increased risk of hypertension (13,14) and vitiligo (15), both conditions that are related to oxidative stress. We previously showed that women with the common CAT CC genotype had a 17% reduction in risk of breast cancer compared with those with at least one T allele (CT and TT genotypes) in the Long Island Breast Cancer Study Project, a large population based case-control study (1,008 cases and 1,056 controls; ref.…”

Section: Introductionmentioning

confidence: 99%

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Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors

Ahn

Nowell

McCann

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

106

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Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. A À262C ! T polymorphism in the promoter region of the gene (CAT) is associated with risk of several conditions related to oxidative stress. We sought to determine the functional effects of the CAT polymorphism on enzyme activity in erythrocytes and the potential modifying effects of demographic and lifestyle factors on genotype/ phenotype relationships, using specimens and data from controls from breast and prostate cancer studies in Arkansas (n = 420). There was a dose-response reduction in catalase activity by genotype, with geometric means of 115.4 units/mg hemoglobin for those with CC genotypes, 82.1 units/mg for those with CT genotypes, and 73.5 units/mg for those with TT genotypes. Associations were only observed among Caucasians (P < 0.0001), with no effects among African Americans (P = 0.91), and were stronger among women than men, although numbers in stratified analyses were small. Differences in catalase activity by genotype were most pronounced among those in the highest tertiles of consumption of fruits and vegetables (À35%, P = 0.003), with weaker relationships among those who were lower consumers (À21.8%, P = 0.16). Among those with CC genotypes, there was no change in activity by consumption, but there were notable decreases in activity by tertiles of consumption for those with at least one T allele. These data indicate that the CAT À262C ! T polymorphism predicts a portion of catalase phenotype, which may be limited to Caucasians. Associations between genotype and phenotype were modified by dietary factors, illustrating the biochemical complexity of studies of genetic polymorphisms and disease risk. (Cancer Epidemiol Biomarkers Prev 2006;15(6):1217 -22)

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors

Ahn

Nowell

McCann

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

106

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“…Consistent with this hypothesis, our results demonstrated that the risk of spontaneous abortion had increased in women with C/C genotype. Reduced risk of the T allele has also been reported in patients with type 1 diabetes [Chistiakov et al 2004], hypertension [Jiang et al 2001], and breast cancer [Ambrosone et al 2005]. Overdominant selection favoring heterozygotes and associative overdominance can lead to excess of heterozygote observed in the results.…”

Section: Resultsmentioning

confidence: 95%

Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion

Sabet

Salehi

Khodayari

et al. 2014

Systems Biology in Reproductive Medicine

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“…25 CAT is an important antioxidant enzyme that detoxifies H 2 O 2 into oxygen and water, and thus limits the deleterious effects of reactive oxygen species (ROS). 15 CAT regulates plasma levels of ROS and together with nitric oxide (NO), influences angiotensin-converting enzyme (ACE) activation, LDL oxidation, adhesion molecule expression, platelet aggregation, endothelial cell apoptosis and vascular smooth cell growth. Most previous studies only considered single-gene effects, although hypertension is a complex multi-factorial and polygenic disorder.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study

et al. 2009

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Hypertension is a complex multi-factorial and polygenic disorder. Nevertheless, most studies have focused on single-gene effects. Furthermore, a majority of these studies have been cross-sectional and diagnosed hypertension using conventional blood pressure (BP) measurements, which are known to be subject to biases, including the so-called white-coat effect. Thus, we performed a longitudinal association study to clarify the effects of polymorphism accumulation on the development of hypertension that is defined on the basis of self-measured BP at home (home BP). In 403 Japanese aged 40-79 years with home normotension (home BP o135/85 mm Hg, and not treated with antihypertensive medication at baseline), we examined the associations of 51 single-nucleotide polymorphisms (SNPs) classically nominated or reported to be associated with hypertension in the Japanese Millennium Genome Project for Hypertension with a 12-year risk of progression to home hypertension (home BP X135/85 mm Hg, or start of antihypertensive medication). Out of 51 SNPs, four significantly and independently predicted the risk of progression of home hypertension, even after adjustment for possible confounding factors, including baseline home BP value. These were rs3767489 near the regulator of G-protein signaling 2 (RGS2), rs4961 in adducin 1 (ADD1), rs2236957 in the calcium channel, voltage-dependent, a-2/d-subunit 2 (CACNA2D2) and rs769214 in catalase (CAT). Accumulation of these SNPs significantly improved the predictive values for the development of home hypertension. In conclusion, this longitudinal study, which was based on home BP measurement, showed that accumulation of common polymorphisms reliably predicted the risk of future hypertension in the Japanese general population.

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A polymorphism in the promoter region of catalase is associated with blood pressure levels

Cited by 92 publications

References 19 publications

Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors

Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors

Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion

Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study

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