A Polymorphism in the CD14 Gene is Associated with Crohn Disease

Klein, Wolfram; Tromm, Andreas; Griga, Thomas; Fricke, Harald; Folwaczny, C; Hocke, Michael; Eitner, K; Marx, Michaela; Duerig, N; Epplen, Jörg T.

doi:10.1080/003655202753416867

Cited by 87 publications

(65 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A polymorphism in the human CD14 promoter (T/C at position Ϫ159) is related to high expression of CD14 (5). This polymorphism was shown to be associated with Crohn's disease and ulcerative colitis (27,41).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, these genes showed very distinct expression differences between the C3 and B6 genetic backgrounds. Gbp1 (26) and Pla2g2a (48) are already known to be polymorphic between C3 and B6 mice, and a polymorphism in the human CD14 gene is associated with IBD in humans (27,41). Therefore, these genes were considered to be the major candidate genes.…”

Section: Determination Of Inflammatory Changes In the Colon Of Il10mentioning

confidence: 99%

See 1 more Smart Citation

Cd14,Gbp1, andPla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

Buhr

Mähler

Geffers

et al. 2006

Physiological Genomics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Determination Of Inflammatory Changes In the Colon Of Il10mentioning

confidence: 99%

Cd14,Gbp1, andPla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

Buhr

Mähler

Geffers

et al. 2006

Physiological Genomics

View full text Add to dashboard Cite

show abstract

“…También se han evaluado aspectos relacionados con la propia enfermedad como los distintos fenotipos en relación con la clasificación de Viena (localización, edad de presentación y comportamiento evolutivo), la presencia de manifestaciones extraintestinales y, los antecedentes quirúrgicos de estos pacientes en relación con su EC. Con la hipótesis de que la predisposición genética pudiese tener valor pronóstico para el desarrollo de hemorragia masiva también se evaluó la presencia de alguna de las tres principales mutaciones del gen NOD2/CARD15 (R702W, G908R y 1007fs) (6) así como la presencia de mutaciones asociada a un polimorfismo en el gen que codifica los receptores toll-like tipo 4 (TLR4) (Asp299Gly) y una mutación en un polimorfismo del gen CD14 (T/C 260), ambas cercanas al gen NOD2 e implicadas en la fisiopatología de la EC (7,8).…”

Section: Materials Y Métodosunclassified

Hemorragia digestiva baja masiva en pacientes con enfermedad de Crohn

Acosta¹,

Rı́os²,

Muñoz³

2007

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Barreiro de Acosta M, Seijo Ríos S, Domínguez Muñoz JE. Hemorragia digestiva baja masiva en pacientes con enfermedad de Crohn. Rev Esp Enferm Dig 2007; 99: 388-391. RESUMENObjetivo: analizar la frecuencia de las hemorragias masivas en la EC e intentar determinar sus potenciales factores de riesgo (ambientales, propios de la enfermedad y genéticos).Material y métodos: se estudió de manera retrospectiva una cohorte de 174 pacientes -103 mujeres (59%) y 71 hombres (41%), edad media de 37 años-con EC, analizándose las hemorragias digestivas masivas que se habían producido en relación con su enfermedad. Se revisaron asimismo potenciales factores de riesgo como hábito tabáquico, localización de la enfermedad y presencia de mutaciones genéticas en CARD15, RTL-4 y CD14, entre otros.Resultados: tres pacientes (1,7%) presentaron una hemorragia digestiva masiva que precisó intervención quirúrgica para su resolución. Esta indicación de cirugía supone el 3,4% de las cirugías en relación con la EC. Todos los pacientes eran jóvenes y su enfermedad seguía un patrón inflamatorio y estaba localizada en el íleon. No se ha evidenciado asociación estadísticamente significativa entre las hemorragias digestivas masivas y los potenciales factores de riesgo analizados.Conclusiones: la hemorragia digestiva baja masiva es una complicación poco común, aunque grave de la EC. Se trata habitualmente de pacientes con patrón inflamatorio de la enfermedad y afectación ileal. Para su diagnóstico resulta clave la asociación de endoscopia y arteriografía, y su resolución suele ser quirúrgica.Palabras clave: Enfermedad de Crohn. Hemorragia. Factores predictivos. ABSTRACTObjective: we aimed at evaluating the frequency of acute severe bleeding in CD and its potential association to some risk factors, including clinical features of CD, environmental factors, and genetic alterations.Material and methods: 174 consecutive patients with CD (103 female (59%) and 71 men (41%), with a mean age of 37 years) were included. We analyzed all major acute lower gastrointestinal (GI) hemorrhage related to CD. Potential risk factors like smoking, site of disease, and presence of gene mutations in CARD15, TLR-4, and CD14 were also analyzed.Results: three patients (1.7%) suffered from severe acute lower GI bleeding. All patients required surgery to resolve their hemorrhage, and this indication represented 3.4% of all surgical procedures related to CD. All three patients were young (< 25 years) and suffered ileal CD with inflammatory pattern (L1-B1 in the Vienna Classification). No relationship was found between acute bleeding and any of the potential risk factors evaluated.Conclusions: acute severe GI bleeding is a rare, but severe complication in CD patients, and presents mainly in patients with inflammatory ileal disease. An association of endoscopy and arteriography is necessary for diagnosis. Urgent surgery is usually required in these patients.Key words: Crohn´s disease. Hemorrhage. Risk factors. INTRODUCCIÓNEl sangrado gastrointestinal bajo se ha descrito en ...

show abstract

“…36,37 A common functional promoter region polymorphism (T-159C) of the CD14 gene has been identified 38 and a weak association with both CD and UC has been demonstrated. [39][40][41] In the present study, we have investigated the contribution of the three common NOD2/CARD15 variants in determining susceptibility and phenotype in a large cohort of Scottish patients with well-characterised CD and UC. We have gone on to compare these data with a cohort of Irish patients who may have common Celtic ancestry, in order to explore the similarity in genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

et al. 2004

View full text Add to dashboard Cite

A Polymorphism in the CD14 Gene is Associated with Crohn Disease

Abstract: An altered immune response to LPS seems to play a role in the genetic predisposition to CD but not to UC.

Cited by 87 publications

References 22 publications

Cd14,Gbp1, andPla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

Cd14,Gbp1, andPla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

Hemorragia digestiva baja masiva en pacientes con enfermedad de Crohn

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

Contact Info

Product

Resources

About