2008
DOI: 10.3892/mmr.1.4.561
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A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer

Abstract: Abstract.A polymorphism within the 3'-UTR 8473T¨C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T¨C polymorphism and gastric cancer development. DNA from 121 Japanese patients with gastric cancer and 126 age-matched control patients was examined for the COX-2 polymorphism by PCR-RFLP. Odds ratios and the 95% confidence interval (CI) were ca… Show more

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“…A variação rs5275, localizada no éxon 10 e que codifica para a região 3'-UTR do gene, parece regular a expressão de COX-2 por meio da regulação pós-transcricional mediada por microRNA (Moore et al, 2012 (Shibata et al, 2008;Dong et al, 2010; e, dessa forma, merecem ser melhor investigados.…”
Section: Cox-2/ptgs2 (Cyclooxygenase-2/prostaglandin-endoperoxide Synunclassified
“…A variação rs5275, localizada no éxon 10 e que codifica para a região 3'-UTR do gene, parece regular a expressão de COX-2 por meio da regulação pós-transcricional mediada por microRNA (Moore et al, 2012 (Shibata et al, 2008;Dong et al, 2010; e, dessa forma, merecem ser melhor investigados.…”
Section: Cox-2/ptgs2 (Cyclooxygenase-2/prostaglandin-endoperoxide Synunclassified