A Polymerized Kappa Light Chain Multiple Myeloma

A suspected case of falsely low digoxin and vancomycin concentrations caused by free kappa light chains with PETINIA method

“…It has been previously shown that free kappa light chains in some patients can exist as a mixture of monomeric, dimetric and even tetrameric forms [ 9 , 10 ]. It is known that when IgM forms polymers, its solubility decreases, hence sample turbidity is increased [ 6 ].…”