A polymeric nanoformulation improves the bioavailability and efficacy of sorafenib for hepatocellular carcinoma therapy

Chen, Yang; Li, Jiaxian; Shu, Na; Zheng, Sui-Juan; Ma, Min; Zhao, Zhibin; Cao, Zhi-Ting; Zhou, Qi; Du, Jin‐Zhi; Wang, Jun

doi:10.1039/d0bm01881c

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…Some drugs, such as sorafenib, have a tumoricidal effect; however, their clinical application is limited due to poor water solubility, fast metabolism, and low oral bioavailability. The nano-delivery system can improve the water solubility and bioavailability of drugs [ 94 , 95 , 142 ]. Chen et al used clinically safe poly(ethylene glycol)-b-poly(lactic acid) as a nanocarrier to deliver sorafenib (NP-sfb), and the inhibition of NP-sfb on tumor growth was significantly stronger than that of free SFB at the same dose, indicating that nanoparticles successfully increased the bioavailability of SFB [ 94 ].…”

Section: Progress In Treatment Of Hcc and Application Of Nanotechnologymentioning

confidence: 99%

Exploiting targeted nanomedicine for surveillance, diagnosis, and treatment of hepatocellular carcinoma

Liu

et al. 2023

Materials Today Bio

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Section: Progress In Treatment Of Hcc and Application Of Nanotechnologymentioning

confidence: 99%

Exploiting targeted nanomedicine for surveillance, diagnosis, and treatment of hepatocellular carcinoma

Liu

et al. 2023

Materials Today Bio

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“…The sorafenib-loaded nanoparticles based on PEG-b-PLA showed satisfactory inhibitory efficacy for HCC cell lines. Conversely, the nanoparticles displayed low cytotoxicity to the normal hepatocyte with the same treatment conditions [ 113 ]. PLGA is one of the synthetic biodegradable polymers obtained from lactic and glycolic acid.…”

Section: Delivery Carriers Of Mtkismentioning

confidence: 99%

Multi-target tyrosine kinase inhibitor nanoparticle delivery systems for cancer therapy

Xu¹,

Ye²,

Qing³

et al. 2022

Materials Today Bio

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“…Hence, a variety of microwave sensitizing nanomaterials have been developed [ 11 – 14 ], such as organic materials (gelatin, sodium alginate microcapsules) [ 15 ], inorganic materials [ 16 – 18 ] (zirconium dioxide hollow nanospheres [ 19 ], carbon nanotubes [ 20 – 22 ]), organic–inorganic hybrid materials (metal organic framework [ 23 – 25 ]). Amongst, synthesis methods and the targeting ability of the organic materials need to be improved [ 26 , 27 ]. The inorganic nanomaterials are unable to be metabolized and difficult to be eliminated from the body, which limits their clinical applications [ 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

Lanthanide europium MOF nanocomposite as the theranostic nanoplatform for microwave thermo-chemotherapy and fluorescence imaging

Zhao

Zhang

et al. 2022

J Nanobiotechnol

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Backgrounds Microwave sensitization nanoplatform, integrating multiple functional units for improving tumor selectivity, is of great significance for clinical tumor microwave treatment. Lanthanide europium metal organic framework (EuMOF) is expected to be a theranostic nanoplatform owing to its unique luminescent and microwave sensitization properties. However, it is difficult to be applied to complicated biological systems for EuMOF due to its rapid degradation induced by the solvent molecular and ionic environment. In this work, a luminescent EuMOF nanocomposite (EuMOF@ZIF/AP-PEG, named EZAP) was designed, which brought the multifunctional characteristics of microwave sensitization, fluorescence imaging and drug loading. Results Lamellar EuMOF was synthesized by a hydrothermal method. Through the charge adsorption mechanism, the zeolite imidazole framework (ZIF) structure was intensively assembled on the surface of EuMOF to realize the protection. Then, through in-situ Apatinib drug loading and PEG modification, EZAP nanocomposite was finally obtained. Apatinib (AP) was a kind of chemotherapy drug approved by Food and Drug Administration for targeted therapy of tumors. PEG modification increased long-term circulation of EZAP nanocomposite. The physical and chemical structure and properties of EuMOF@ZIF (EZ) were systematically represented, indicating the successful synthesis of the nanocomposite. The toxic and side effects were negligible at a safe dose. The growth of human liver cancer cells and murine liver cancer cells in vitro was significantly inhibited, and the combined microwave-thermal therapy and chemotherapy in vivo achieved high anti-cancer efficacy. Moreover, EZAP nanocomposite possessed bright red fluorescence, which can be applied for tumor imaging in tumor-bearing mice in vivo. Conclusion Therefore, EZAP nanocomposite showed high microwave sensitization, excellent fluorescence properties and outstanding drug loading capacity, establishing a promising theranostic nanoplatform for tumor therapy and fluorescence imaging. This work proposes a unique strategy to design for the first time a multifunctional nanoplatform with lanthanide metal organic frameworks for biological applications in tumor therapy and diagnosis. Graphical Abstract

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A polymeric nanoformulation improves the bioavailability and efficacy of sorafenib for hepatocellular carcinoma therapy

Abstract: A nanoparticle-based formulation of sorafenib (NP-sfb) significantly inhibited hepatocellular carcinoma by suppressing angiogenesis and promoting cytotoxic T lymphocyte infiltration.

Cited by 7 publications

References 35 publications

Exploiting targeted nanomedicine for surveillance, diagnosis, and treatment of hepatocellular carcinoma

Exploiting targeted nanomedicine for surveillance, diagnosis, and treatment of hepatocellular carcinoma

Multi-target tyrosine kinase inhibitor nanoparticle delivery systems for cancer therapy

Lanthanide europium MOF nanocomposite as the theranostic nanoplatform for microwave thermo-chemotherapy and fluorescence imaging

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