A polymer encapsulation approach to prepare zwitterion-like, biocompatible quantum dots with wide pH and ionic stability

Huang, Liming; Liao, Mingxia; Chen, Siqi; Demillo, Violeta G.; duPré, Sally A.; Zhu, Xiaoshan; Publicover, Nelson G.; Hunter, Kenneth W.

doi:10.1007/s11051-014-2555-3

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…Suitable polymers can be further crosslinked and an additional shell can be produced around the QDs. Such a behavior has been shown, for example, in copolymers from maleic acid anhydride and 1-octadecene or 1-tetradecene [32][33][34].…”

Section: Introductionmentioning

confidence: 78%

Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media

et al. 2020

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Highly luminescent indium phosphide zinc sulfide (InPZnS) quantum dots (QDs), with zinc selenide/zinc sulfide (ZnSe/ZnS) shells, were synthesized. The QDs were modified via a post-synthetic ligand exchange reaction with 3-mercaptopropionic acid (MPA) and 11-mercaptoundecanoic acid (MUA) in different MPA:MUA ratios, making this study the first investigation into the effects of mixed ligand shells on InPZnS QDs. Moreover, this article also describes an optimized method for the correlation of the QD size vs. optical absorption of the QDs. Upon ligand exchange, the QDs can be dispersed in water. Longer ligands (MUA) provide more stable dispersions than short-chain ligands. Thicker ZnSe/ZnS shells provide a better photoluminescence quantum yield (PLQY) and higher emission stability upon ligand exchange. Both the ligand exchange and the optical properties are highly reproducible between different QD batches. Before dialysis, QDs with a ZnS shell thickness of ~4.9 monolayers (ML), stabilized with a mixed MPA:MUA (mixing ratio of 1:10), showed the highest PLQY, at ~45%. After dialysis, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with a mixed MPA:MUA and a ratio of 1:10 and 1:100, showed the highest PLQYs, of ~41%. The dispersions were stable up to 44 days at ambient conditions and in the dark. After 44 days, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with only MUA, showed the highest PLQY, of ~34%.

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Section: Introductionmentioning

confidence: 78%

Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media

et al. 2020

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“…In a more recent study, the cytotoxicity of zwitterion-like CuInS 2 /ZnS QDs (ZWL-QDs) toward human primary glioblastoma (U-87 MG) cells and human embryonic kidney 293 (HEK-293) cells was assessed. 545 The cell viability was determined by staining the cells with FDA/PI to differentiate between live and dead cells. Both U-87MG and HEK-293 cells were treated with 20 nM of the ZWL-QDs, and untreated cells were used as controls.…”

Section: In Vitro Toxicitymentioning

confidence: 99%

New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine

et al. 2016

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This review summarizes recent progress in the design and applications of cadmium-free quantum dots (Cd-free QDs), with an emphasis on their role in biophotonics and nanomedicine. We first present the features of Cd-free QDs and describe the physics and emergent optical properties of various types of Cd-free QDs whose applications are discussed in subsequent sections. Selected specific QD systems are introduced, followed by the preparation of these Cd-free QDs in a form useful for biological applications, including recent advances in achieving high photoluminescence quantum yield (PL QY) and tunability of emission color. Next, we summarize biophotonic applications of Cd-free QDs in optical imaging, photoacoustic imaging, sensing, optical tracking, and photothermal therapy. Research advances in the use of Cd-free QDs for nanomedicine applications are discussed, including drug/gene delivery, protein/peptide delivery, image-guided surgery, diagnostics, and medical devices. The review then considers the pharmacokinetics and biodistribution of Cd-free QDs and summarizes current studies on the in vitro and in vivo toxicity of Cd-free QDs. Finally, we provide perspectives on the overall current status, challenges, and future directions in this field.

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“…The first one is based on the addition of an amphiphilic molecule to the external surface of the NPs, without the removal of the capping agent. The hydrophobic interaction between the two amphiphilic molecules creates a two-layer structure exposing a hydrophilic surface, on the surface of the NP, thus allowing the dispersion in water [ 29 , 30 , 31 ]. The second kind of functionalization is based on the substitution of the capping agent used in the synthesis by replacing it with a bi-functional molecule formed by a functional group able to bind to the NPs surface and a second polar group that makes the compound soluble in water [ 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Towards the Development of Antioxidant Cerium Oxide Nanoparticles for Biomedical Applications: Controlling the Properties by Tuning Synthesis Conditions

et al. 2021

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In this work CeO2 nanoparticles (CeO2-NPs) were synthesized through the thermal decomposition of Ce(NO3)3·6H2O, using as capping agents either octylamine or oleylamine, to evaluate the effect of alkyl chain length, an issue at 150 °C, in the case of octylamine and at 150 and 250 °C, in the case of oleylamine, to evaluate the effect of the temperature on NPs properties. All the nanoparticles were extensively characterized by a multidisciplinary approach, such as wide-angle X-ray diffraction, transmission electron microscopy, dynamic light scattering, UV-Vis, fluorescence, Raman and FTIR spectroscopies. The analysis of the experimental data shows that the capping agent nature and the synthesis temperature affect nanoparticle properties including size, morphology, aggregation and Ce3+/Ce4+ ratio. Such issues have not been discussed yet, at the best of our knowledge, in the literature. Notably, CeO2-NPs synthesized in the presence of oleylamine at 250 °C showed no tendency to aggregation and we made them water-soluble through a further coating with sodium oleate. The obtained nanoparticles show a less tendency to clustering forming stable aggregates (ranging between 14 and 22 nm) of few NPs. These were tested for biocompatibility and ROS inhibiting activity, demonstrating a remarkable antioxidant activity, against oxidative stress.

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A polymer encapsulation approach to prepare zwitterion-like, biocompatible quantum dots with wide pH and ionic stability

Cited by 13 publications

References 24 publications

Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media

Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media

New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine

Towards the Development of Antioxidant Cerium Oxide Nanoparticles for Biomedical Applications: Controlling the Properties by Tuning Synthesis Conditions

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