A polyelectrolyte based ratiometric optical sensor for Arginine and Lysine

Pandey, Shrishti P.; Singh, Prabhat

doi:10.1016/j.snb.2019.127182

Cited by 49 publications

(11 citation statements)

References 57 publications

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“…However, this is not an issue for our assay as it responds well to most NCOBs (and not limited to examples we tested). (2) In addition to its broad scope, our assay is also very sensitive: out of the 11 example NCOBs we tested, 2 of them have never been achieved in literature before; and 5 of them are much better in terms of their sensitivity (or LOD) than the best results reported in literature ( Table S2 ) [ 22 , 23 , 24 , 25 , 26 ]. (3) The assay could distinguish NCOBs from oxygen and sulfur containing organics very well.…”

Section: Resultsmentioning

confidence: 92%

“…Detection of tetracycline using UV-vis absorption-based sensing assay; Figure S12: Detection of butylamine using PL-based sensing assay; Figure S13: Detection of spermine using PL-based sensing assay; Figure S14: Detection of aniline using PL-based sensing assay; Figure S15: Detection of pyrrole using PL-based sensing assay; Figure S16: Detection of imidazole using PL-based sensing assay; Figure S17: Detection of purine using PL-based sensing assay; Figure S18: Detection of quinoline using PL-based sensing assay; Figure S19: Detection of indole using PL-based sensing assay; Figure S20: Detection of tetracycline using PL-based sensing assay; Table S1: Summary of differences between calculated values and the actual values in percentage (Diff. %) of UV-vis absorption- and PL-based assays for the detection of various NCOBs; Table S2: Comparison of the performance of NCOBs sensing reported in this work to that of prior art [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

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confidence: 99%

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Facile and Sensitive Detection of Nitrogen-Containing Organic Bases with Near Infrared C-Dots Derived Assays

Zhou

Shi

et al. 2021

Nanomaterials

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In this article, we have designed both colorimetric (including solution and test paper type) and spectral sensors (including UV-vis and PL type) for the quick and sensitive detection of general nitrogen-containing organic bases (NCOBs); the limit of detection could reach as low as 0.50 nM. NCOBs included 11 examples, covering aliphatic and aromatic amines, five- and six-membered heterocyclics, fused-ring heterocyclics, amino acids, and antibiotics. Furthermore, the assays demonstrated high reliability in sensing NCOBs and excellent ability to distinguish NCOBs from oxygen and sulfur containing organics. The assays developed could find important applications for the detection of NCOBs in the fields of biomedicine, chemistry, and agriculture.

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Section: Resultsmentioning

confidence: 92%

mentioning

confidence: 99%

Facile and Sensitive Detection of Nitrogen-Containing Organic Bases with Near Infrared C-Dots Derived Assays

Zhou

Shi

et al. 2021

Nanomaterials

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“…In this regard, it has been previously reported that the high negative charge density of PSS causes neutralization of positively charged guest molecules, owing to the presence of sulfonate groups, ultimately leading to their aggregation, 23,55 and produces emission spectra displaying a large redshift along with broadening. 23 Note that, in the present case, we are also dealing with a positively charged molecule, i.e., BO21, and thus, it is likely that BO21 undergoes aggregation in the presence of negatively charged PSS.…”

Section: Methodsmentioning

confidence: 99%

“…Polyelectrolytes have been extensively utilized by researchers as a template to induce aggregation of oppositely charged organic dyes. − Polystyrene sulfonate (PSS) is one such anionic polyelectrolyte that has been recently utilized for the aggregation of cationic organic dyes forming dye–polyelectrolyte aggregate assemblies, which have been further utilized for the sensing of important amino acids and proteins. ,,− …”

Section: Introductionmentioning

confidence: 99%

Anionic Polyelectrolyte-Induced Aggregation of Basic Orange 21: A Clue toward Metachromasia

2021

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The change in the color of chromophore upon being embedded in a biological tissue is known as metachromasia. Basic Orange 21 (BO21) is a cationic polymethine dye that has been implied as a supravital dye, which produces metachromasia in leukocytes. An improved differential counting of leukocytes has been achieved in the clinical setup based on characteristic metachromatic expressions of BO21 for different types of leukocytes. Although BO21 has been utilized as a chromatic indicator for leukocyte counting, there are limited number of investigations that focus on the factors that may be responsible for the spectral shift in absorption and emission spectra of BO21, which leads to its metachromatic behavior. In this work, we have investigated the effect of a synthetic anionic polyelectrolyte, polystyrene sulfonate (PSS), on the photophysical properties of BO21, using steady-state emission, ground-state absorption, and time-resolved emission measurements, to get an understanding of the factors that may be responsible for the spectral shift of BO21 in the cellular environment. PSS induces aggregation of BO21 molecules with large changes in its photophysical properties; this appears to be most likely the mechanism of spectral shift for BO21 reported in the cellular environment. The employment of external stimulus reveals BO21 aggregates to be significantly responsive toward external stimuli, for example, temperature and presence of salt in the medium, which further strengthens the proposal of aggregate formation. Further, we have also employed fluorescence upconversion spectroscopy with subpicosecond time resolution to estimate the excited-state lifetime of BO21.

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“…In this respect, the derivatives of tetraphenylethylene (TPE) are one of the most popular class of AIEgens used to design optical sensing platforms. , Further, in order to attain dynamic controllability, good reversibility, and stimuli responsiveness to the external factors, probes based on noncovalent interactions are highly preferred. ,− In this regard, to design turn-on probes, rotational motions of AIEgens have been restricted via various noncovalent interactions, such as, co-ordinate bonding, electrostatic interactions, and hydrophobic forces offered by various biopolymers, such as, proteins, enzymes, DNA, peptides, glycosaminoglycans, etc. − Especially, the ionic backbone structure or grooves and cavities of the biopolymers have been shown to arrest the intramolecular motions of AIEgens, leading to enhanced fluorescence. ,− Moreover, in the last decade, electrostatic interactions have been extensively employed to develop such probing systems in diverse fields for monitoring analytes, molecular recognition, drug delivery, supramolecular catalysis, etc. ,− …”

Section: Introductionmentioning

confidence: 99%

Polyanionic Cyclodextrin-Induced Supramolecular Assembly of a Cationic Tetraphenylethylene Derivative with Aggregation-Induced Emission

et al. 2022

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The combination of supramolecular chemistry and aggregation-induced emission-based luminogens (AIEgens) has recently attracted tremendous attention because of its ability to offer large emission enhancement even in substantially dilute solutions. In this work, a new aggregation-induced emission (AIE)-based supramolecular assembly has been reported, which consists of a polyanionic cyclodextrin derivative and a tetracationic tetraphenylethylene (TPE) derivative. Ionic cyclodextrins have attracted significant attention in host–guest supramolecular chemistry and pharmaceutical industry. However, ionic derivatives of β-cyclodextrins have not been explored to establish noncovalent interactions-based aggregation assembly of the most popular class of AIEgens, i.e., tetraphenylethylene derivatives. The current report demonstrates AIE of a tetracationic methyl pyridinium derivative of tetraphenylethylene (TPy-TPE) induced by a polyanionic sulfated β-cyclodextrin (S-βCD). The AIE-based supramolecular assembly has been thoroughly investigated using steady-state fluorescence, ground-state absorbance, and time-resolved fluorescence measurements. Further, the response of the supramolecular assembly towards external stimuli, such as, ionic strength, pH, and temperature, has been investigated. In addition, the complexation behavior of the TPE derivative has also been compared with the native neutral β-cyclodextrin derivative, which delineates the important role of the negatively charged portal of S-βCD in inducing aggregation of the TPy-TPE. The stoichiometry of the complex has been found to be 3:1 for TPy-TPE:S-βCD, using Job’s plot analysis. Finally, to get insights into the underlying interactions between the supramolecular assembly components, molecular docking calculations have been performed.

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A polyelectrolyte based ratiometric optical sensor for Arginine and Lysine

Cited by 49 publications

References 57 publications

Facile and Sensitive Detection of Nitrogen-Containing Organic Bases with Near Infrared C-Dots Derived Assays

Facile and Sensitive Detection of Nitrogen-Containing Organic Bases with Near Infrared C-Dots Derived Assays

Anionic Polyelectrolyte-Induced Aggregation of Basic Orange 21: A Clue toward Metachromasia

Polyanionic Cyclodextrin-Induced Supramolecular Assembly of a Cationic Tetraphenylethylene Derivative with Aggregation-Induced Emission

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