A poloxamer/hyaluronic acid/chitosan-based thermosensitive hydrogel that releases dihydromyricetin to promote wound healing

Zhao, Yingchun; Liu, Xinglong; Peng, Xiaojuan; Zheng, Yi-Nan; Cheng, Zhiqiang; Sun, Shuwen; Ding, Qiteng; Liu, Wencong; Ding, Chuanbo

doi:10.1016/j.ijbiomac.2022.06.210

Cited by 33 publications

(8 citation statements)

References 65 publications

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“…Poloxamers, also known as Pluronic, is the most common polymer to form a thermosensitive hydrogel. 27 Among the variants of poloxamers, P407 is widely used as a hydrogel-forming material owing to its low toxicity and high solubility in water; P407 has the lowest hydrogel-forming concentration of ca. 17% (w/v), which is usually not resistant to water dilution when applied in mucosal tissue.…”

Section: Resultsmentioning

confidence: 99%

Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

Li,

Shangguan,

et al. 2024

ACS Appl. Mater. Interfaces

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The pathogenesis of ulcerative colitis (UC) is associated with the shedding of the gut mucus. Herein, inspired by the biological functions of mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment by integrating dihydrocaffeic acid-modified poloxamer as a thermosensitive material with hyaluronic acid (colitis-specific adhesive), epigallocatechin-3-gallate (antibacterial agent), and bioactive factors (KPV tripeptide and epidermal growth factor). PHE-EK presented good thermosensitive properties, as a flowable liquid at room temperature and gelled within 10 s when exposed to body temperature. PHE-EK hydrogel presented good mechanical strength with a strain of 77.8%. Moreover, PHE-EK hydrogel displayed antibacterial activity against Escherichia coli. Importantly, in vitro and in vivo adhesive tests showed that the PHE-EK hydrogel could specifically adhere to the inflamed colon via electrostatic interaction. When PHE-EK as a biomimetic mucus was rectally administrated to colitis rats, it effectively hindered the body weight loss, reduced the disease activity index and improved the colonic shorting. Moreover, the expression of pro-inflammatory cytokines (e.g., IL-1β, IL-6, and TNF-α) at the laminae propria or epitheliums of the colon for colitis rats was substantially inhibited by PHE-EK. Besides, the colonic epitheliums were well rearranged, and the tight junction proteins (Zonula-1 and Claudin-5) between them were greatly upregulated after PHE-EK treatment. Collectively, PHE-EK might be a promising therapy for UC.

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Section: Resultsmentioning

confidence: 99%

Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

Li,

Shangguan,

et al. 2024

ACS Appl. Mater. Interfaces

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“…Kim et al investigated the capability of skin-derived extracellular matrix (S-dECM) bio-ink for 3D-cell-printing-based skin tissue engineering using human neonatal dermal fibroblasts and human neonatal epidermal keratinocytes [153]. HaCaT cells were used to investigate the skin regenerative properties of cellulose [165,166], chitosan [167], gelatin [166], polyvinylpyrrolidone [152], poly-ε-caprolactone/collagen [168], and hyaluronic acid [169,170]. Several polymers were tested with adipose-tissue-derived or bone-marrow-derived mesenchymal stem cells to prove their skins' regenerative properties [171][172][173][174][175].…”

Section: Types Of Cells Used As In Vitro Models For Skin Regenerationmentioning

confidence: 99%

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Elango,

Zamora-Ledezma,

Maté-Sánchez de Val

2023

J. Compos. Sci.

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Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is the use of polymer-based systems due to their excellent beneficial properties to the skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin and fibroin, have been tested and have proven the benefits for skin regeneration, and most of them are derived from either polysaccharide- or protein-based materials. In order to understand the mode of action, several researchers investigated the cell–matrix interaction and possible signaling mechanism in skin regeneration. Not only the signaling mechanism but also the mode of cell communication determines the application of polysaccharide- and protein-based polymers in practice. Based on the above significance, this review disclosed the recent findings to compile a possible method of communication between cells and polymers derived from polysaccharide-based (such as cellulose, hyaluronan, chitosan, alginate, agar, and xanthan gum) and protein-based (such as collagen, gelatin, fibrin, and silk fibroin) materials along with other polymers, such as poly(vinyl alcohol), polyglycolide or poly(glycolic acid), or poly(lactic acid) in skin regeneration. Accordingly, this review addresses the fundamental concept of cell–matrix communication, which helps us to understand the basis of the polymer’s functions in the biomedical field.

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“…Zhao et al designed a 37 °C-sensitive hydrogels system using poloxamer 407 as a thermosensitive matrix with chitosan and hyaluronic acid, loaded with dihydromyricetin as a wound dressing. 113 They took the gelation time and temperature as response values to optimize the proportion of various materials and obtained the formula that can be used as a gel at the temperature closest to the human body. Then, 10% dihydromyricetin was added to the gel for structural characterization.…”

Section: Various Types Of Thermosensitive Hydrogel Dressingsmentioning

confidence: 99%

Research progress related to thermosensitive hydrogel dressings in wound healing: a review

Gu,

Zhou,

Zhang

et al. 2023

Nanoscale Adv.

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A poloxamer/hyaluronic acid/chitosan-based thermosensitive hydrogel that releases dihydromyricetin to promote wound healing

Cited by 33 publications

References 65 publications

Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Research progress related to thermosensitive hydrogel dressings in wound healing: a review

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