Abstract:Background
Polo-like kinases (PLKs) are conserved serine/threonine kinase, regulating cell cycle. Giardia lamblia PLK (GlPLK) role in its cell has not been yet studied. Here, the function of GlPLK was investigated to provide the insight of roles in Giardia cell division, especially during cytokinesis and in flagella formation.
Methods
To access the function of GlPLK, Giardia trophozoites were treated with PLK-specific inhibitor, GW843286X (GW) or anti-glplk morpholino, then growth of the cells was monitored … Show more
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