A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study

New Independent Thermobalancing Treatment with Therapeutic Device for Chronic Prostatitis/Chronic Pelvic Pain Syndrome

“…Shoskes (10) in his review in 2002 has noticed that among plentiful herbal treatments the promising include zinc, cernilton (bee pollen), quercetin, and saw palmetto. About 69% of pollen extract patients showed a 25% improvement compared to 48.5% of placebo patients has shown the clinical trial published in 2009 (11). Thus, pollen extracts (Cernilton) compares favorably to other phytotherapeutics agents: quercetin, and saw palmetto (Serenoa repens) (12).…”

Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline

“…Randomised, sham-controlled studies (n = 39-89) support these results; a 10-week course of acupuncture proved almost twice as likely as sham treatment to improve CP/CPPS symptoms [96], while a three-arm trial showed that after 6 weeks of electro-acupuncture, the NIH-CPSI total score had decreased significantly vs the sham and advice and exercise groups alone (P < 0.001) [97]. A recent review of the evidence on the use of acupuncture in prostatitis concluded that the findings should encourage healthcare providers to use acupuncture to manage pain in CP/CPPS, in conjunction with standard treatment [98] Phytotherapy Three small RCTs were identified that evaluated phytotherapy in CP/CPPS [99][100][101]. In a trial of a rye pollen extract (Cernilton) (n = 70) vs placebo (n = 69), the pollen extract significantly improved total, pain and QoL NIH-CPSI scores in patients with inflammatory CP/CPPS vs placebo, without any severe adverse effects [101].…”

“…A recent review of the evidence on the use of acupuncture in prostatitis concluded that the findings should encourage healthcare providers to use acupuncture to manage pain in CP/CPPS, in conjunction with standard treatment [98] Phytotherapy Three small RCTs were identified that evaluated phytotherapy in CP/CPPS [99][100][101]. In a trial of a rye pollen extract (Cernilton) (n = 70) vs placebo (n = 69), the pollen extract significantly improved total, pain and QoL NIH-CPSI scores in patients with inflammatory CP/CPPS vs placebo, without any severe adverse effects [101]. Significant differences between another pollen extract (Prostat/Poltit) and placebo were demonstrated in a small (n = 60) trial, but a validated tool for symptom scoring was not used [99].…”

Pharmacotherapy strategies in chronic prostatitis/chronic pelvic pain syndrome management

“…Response, defined as a decrease of the NIH-CPSI total score by at least 25% or at least 6 points, was seen in the pollen extract versus placebo group in 70.6 and 50.0% (p = 0.0141), respectively. The mean decrease in total NIH-CPSI score was 7.7 [40].…”