A police case: Finding propylene glycol guilty as culprit allergen

Barakat, Leyla; Dereure, O.; Raison‐Peyron, Nadia

doi:10.1111/cod.13900

Cited by 2 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moisturizers, topical minoxidil and diclofenac gel were also sources of PG in our study causing ACD and have been previously described in the literature 46,47 . Other topical medications reported include fluorouracil cream, 48 antiviral acyclovir cream, 49–51 ketoconazole cream 52 and transdermal estradiol patches 53 …”

Section: Discussionsupporting

confidence: 65%

“…45 Moisturizers, topical minoxidil and diclofenac gel were also sources of PG in our study causing ACD and have been previously described in the literature. 46,47 Other topical medications reported include fluorouracil cream, 48 antiviral acyclovir cream, [49][50][51] ketoconazole cream 52 and transdermal estradiol patches. 53 Allergic reactions to PG were associated with PCPs in two patients (22.2% of relevant positive reactions), which is much lower than the 53.8% reported in the NACDG study.…”

Section: Concomitant Allergic Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

Allergic contact dermatitis from propylene glycol: A case series from Australia

2023

View full text Add to dashboard Cite

Background Propylene glycol (PG) is used in a variety of cosmetics, food and pharmaceuticals. PG is a known sensitizer but also irritating when patch tested (PT). Objectives The aims were to investigate the frequency of contact sensitization to PG and to identify cases of allergic contact dermatitis (ACD). Methods A retrospective study was performed on patients PT at the Skin Health Institute (SHI), Victoria, Australia to PG 5% pet. and PG 10% aq. between 1 January 2005 and 31 December 2020. Results In all, 6761 patients were PT to PG and 21 (0.31%) reacted. Of those 21 individuals, 9 (42.9%) had a relevant reaction. 75% of relevant positive reactions were in patients PT to PG 10% aq. The most common source of PG exposure was topical medicaments (77.8% of relevant reactions) and moisturizers, with the largest group being topical corticosteroids. Conclusion Contact sensitization to PG in the patch test population remains uncommon, although it is possible that testing with concentrations of 5%–10% PG did not identify all reactions. Topical corticosteroids were the most important cause. Patients with suspected contact dermatitis to topical corticosteroids should be PT to PG.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Concomitant Allergic Reactionsmentioning

confidence: 99%

Allergic contact dermatitis from propylene glycol: A case series from Australia

2023

View full text Add to dashboard Cite

show abstract

“…Some more specific uses of propylene glycol include as a pharmaceutical solvent for oral, topic, and injected medicines, as well in personal care products, such as toothpaste and hand sanitizer, in addition to in cleaning products [42,43]. However, some studies have shown that propylene glycol can cause contact dermatitis in a small percent of people and that rapid, large intravenous doses can be toxic [44][45][46][47]. While these health effects necessitate more research, the consensus is that propylene glycol is safe for human use and consumption [48].…”

Section: Introductionmentioning

confidence: 99%

Survivorship-Reducing Effect of Propylene Glycol on Vector Mosquito Populations and Its Potential Use in Attractive Toxic Sugar Baits

Lindsley

Lyons

Leon-Noreña

et al. 2022

Insects

View full text Add to dashboard Cite

Arthropod control mechanisms are a vital part of public health measures around the world as many insect species serve as vectors for devastating human diseases. Aedes aegypti (Linnaeus, 1762) is a widely distributed, medically important mosquito species that transmits viruses such as yellow fever, Dengue, and Zika. Many traditional control mechanisms have become less effective due to insecticide resistance or exhibit unwanted off-target effects, and, consequently, there is a need for novel solutions. The use of attractive toxic sugar baits (ATSBs) has increased in recent years, though the toxic elements are often harmful to humans and other vertebrates. Therefore, we are investigating propylene glycol, a substance that is generally regarded as safe (GRAS) for human consumption. Using a series of feeding assays, we found that propylene glycol is highly toxic to Ae. aegypti adults and a single day of exposure significantly reduces the survivorship of test populations compared with controls. The effects are more pronounced in males, drastically reducing their survivorship after one day of consumption. Additionally, the consumption of propylene glycol reduced the survivorship of two prominent disease vectors: Aedes albopictus (Skuse, 1894) and Culex pipiens (Linnaeus, 1758). These findings indicate that propylene glycol could be used as a safe and effective alternative to pesticides in an ATSB system.

show abstract

A police case: Finding propylene glycol guilty as culprit allergen

Cited by 2 publications

References 9 publications

Allergic contact dermatitis from propylene glycol: A case series from Australia

Allergic contact dermatitis from propylene glycol: A case series from Australia

Survivorship-Reducing Effect of Propylene Glycol on Vector Mosquito Populations and Its Potential Use in Attractive Toxic Sugar Baits

Contact Info

Product

Resources

About