A pneumatic micromixer facilitating fluid mixing at a wide range flow rate for the preparation of quantum dots

Wang, Xin; Ma, Xiufeng; An, LanLan; Kong, Xiangwei; Xu, Zhang-Run; Wang, Jianhua

doi:10.1007/s11426-012-4808-2

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…Active micromixers depend on different external energy sources to disturb the fluids, increase the contact area, or induce the chaotic advection, thus enhancing the mixing effect. Based on the types of external energy sources, the active micromixers can be further categorized as pressure field driven [ 7 , 13 , 14 , 15 , 16 ], electrical field driven [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], sound field driven [ 6 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], magnetic field driven [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ], and thermal field driven [ 58 ,…”

Section: Active Micromixersmentioning

confidence: 99%

“…Another typical pressure field driven micromixer is based on oscillatory perturbation, which is generated by extruding and vibrating the side channels [ 4 , 7 , 13 , 14 , 71 ]. Lee et al [ 71 ] presented a typical micromixer with periodic pressure perturbations in the side channels to fold and stretch the main stream.…”

Section: Active Micromixersmentioning

confidence: 99%

“…Lee et al [ 71 ] presented a typical micromixer with periodic pressure perturbations in the side channels to fold and stretch the main stream. A common pneumatic micromixer is shown in Figure 1 d [ 13 ], which was comprised of an S-shaped structure with two mixing chambers, two barriers and two pneumatic chambers. With a pumping frequency of 50 Hz, the micromixer could achieve efficient mixing over a wide range of flow rates from 1 μL/min to 650 μL/min.…”

Section: Active Micromixersmentioning

confidence: 99%

“… Schematic of pressure field driven micromixers with ( a ) a main channel and a side channel; ( b ) a main channel and multiple side channels; ( c ) two cross channels; ( d ) two mixing chambers, two barriers and two pneumatic chambers; and ( e ) Braille pin actuator. Reproduced with permission from [ 13 , 14 , 64 , 65 ]. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

A Review on Micromixers

et al. 2017

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Microfluidic devices have attracted increasing attention in the fields of biomedical diagnostics, food safety control, environmental protection, and animal epidemic prevention. Micromixing has a considerable impact on the efficiency and sensitivity of microfluidic devices. This work reviews recent advances on the passive and active micromixers for the development of various microfluidic chips. Recently reported active micromixers driven by pressure fields, electrical fields, sound fields, magnetic fields, and thermal fields, etc. and passive micromixers, which owned two-dimensional obstacles, unbalanced collisions, spiral and convergence-divergence structures or three-dimensional lamination and spiral structures, were summarized and discussed. The future trends for micromixers to combine with 3D printing and paper channel were brought forth as well.

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Section: Active Micromixersmentioning

confidence: 99%

Section: Active Micromixersmentioning

confidence: 99%

Section: Active Micromixersmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

A Review on Micromixers

et al. 2017

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“…A serpentine micromixer can be employed to enhance the length of the channel, having been employed for the synthesis of Au nanoparticles in a ceramic microfluidic system . Convective micromixers or pneumatic micromixer can also be integrated as part of the microchannels to further improve the mixing . Raw materials can be loaded together with then flow through a single coiled capillary reactor (Figure c) or separately loaded with the flowing liquids mixed using a y‐shaped MD (Figure b).…”

Section: Classification Of Microfluidic Synthesis Systemsmentioning

confidence: 99%

Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Luo

Zhang

et al. 2019

Adv Materials Technologies

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Nano or microsized particles have been a research focus for decades, and the advancement of microfluidic technologies provides alternative strategies for the synthesis of such materials for various applications. Recent advances of using different microfluidic devices (MDs), including continuous laminar flow, segmented flow, droplet‐based, and other non‐chip‐based microreactors, for the synthesis of nano or microsized particles with specific properties are reviewed, along with their biomedical applications. Different categories of particles fabricated in MDs are summarized to highlight the wide application of the processing platform in the development of novel functional materials.

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Microfluidic Bioreactor with Fibrous Micromixers for In Vitro mRNA Transcription

et al. 2023

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A new type of microfluidic bioreactor with fibrous micromixers for the ingredient mixing and a long macrochannel for the in vitro transcription reaction was fabricated for the continuous production of mRNA. The diameter of the fibrous microchannels in the micromixers was tuned by using an electrospun microfibrous disc with different microfiber diameters. The micromixer with a larger diameter of fibrous microchannels exhibited a better mixing performance than the others. The mixing efficiency was increased to 0.95 while the mixture was passed through the micromixers, suggesting complete mixing. To demonstrate the continuous production of mRNA, the ingredients for in vitro transcription were introduced into the perfluoropolyether microfluidic bioreactor. The mRNA synthesized by the microfluidic bioreactor had the same sequence and in vitro/in vivo performances as those prepared by the bulk reaction. The continuous reaction in the microfluidic bioreactor with efficient mixing performance can be used as a powerful platform for various microfluidic reactions.

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A pneumatic micromixer facilitating fluid mixing at a wide range flow rate for the preparation of quantum dots

Cited by 16 publications

References 32 publications

A Review on Micromixers

A Review on Micromixers

Microfluidic Devices in Fabricating Nano or Micromaterials for Biomedical Applications

Microfluidic Bioreactor with Fibrous Micromixers for In Vitro mRNA Transcription

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