A Pleiotropic Nuclear Hormone Labelled Hundred Years Ago Vitamin D

Carlberg, Carsten

doi:10.3390/nu15010171

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Timmers et al noted that 40% of the children had deficient levels and 38% insufficient levels [42]. Furthermore, in our series, two heterozygous adults had severe hypovitaminosis D. Severe deficiency can cause bone malformations in children (rickets) and adults (osteomalacia) [19,47], and it can dramatically increase the risk of mortality, infections, and many other diseases [48].…”

Section: Vitamin Dmentioning

confidence: 54%

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Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Escobedo-Monge,

Marcos-Temprano,

Parodi-Román

et al. 2024

IJMS

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Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.

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Section: Vitamin Dmentioning

confidence: 54%

“…In CF patients, Vit-D is essential for bone, immune, gastrointestinal (GI) and lung health [18]. At any age, Vit-D deficiency can cause immunodeficiency disorders, with the consequent risk of infectious, as well as the occurrence and progression of autoimmune diseases [19,20].…”

Section: Introductionmentioning

confidence: 99%

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Escobedo-Monge,

Marcos-Temprano,

Parodi-Román

et al. 2024

IJMS

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“…The value of 30 ng/mL corresponds to the minimum plateau value of PTH and, therefore, should be fine with regard to the skeletal action of vitamin D. However, there are extraskeletal effects of vitamin D. These non-skeletal effects occur at concentrations higher than 30 ng/mL, probably between 40 ng/mL and 60 ng/mL [20]. It has been reported that concentrations above 50 ng/mL can increase the expression of VDR mRNA [9] and that calcitriol binds to VDR with a K d of 0.1 nM [7]. So, at higher concentrations, vitamin D binds to its receptor and forms a heterodimer with the vitamin A receptor, exerting its anti-inflammatory action.…”

Section: Low Levels Of Vitamin D Could Be a Marker Of Potential Predi...mentioning

confidence: 99%

“…In fact, we must consider that the active form of vitamin D 3 behaves like a hormone by binding to a nuclear receptor/transcription factor, called VDR, which has numerous pleiotropic effects at the level of the immune, cardiovascular, neurological, and intestinal systems [5][6][7]. These effects, which have not yet been taken into due consideration by government institutions, are often associated with the inflammatory diseases of our time.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D, the Sunshine Molecule That Makes Us Strong: What Does Its Current Global Deficiency Imply?

Riccio

2024

Nutrients

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Vitamin D3 deficiency and insufficiency are becoming a common global issue for us, especially in the most industrially developed countries. The only acknowledged activity of vitamin D3 in vertebrates is to promote the absorption of calcium and, therefore, allow for the mineralization of bones. Accordingly, its deficiency is associated with diseases such as rickets. Other numerous vital functions associated with vitamin D3 are yet to be considered, and the function of vitamin D2 in plants is unknown. Thus, 100 years after its discovery, the importance of vitamin D still seems to be unacknowledged (except for rickets), with little attention given to its decrease throughout the world. In this review, I suggest that vitamin D deficiency and insufficiency may be linked to the westernized lifestyle in more developed countries. Furthermore, I suggest that, rather than the calcemic activity, the main function of vitamin D is, in general, that of strengthening living organisms. I conclude with the hypothesis that vitamin D deficiency may represent a marker for a greater risk of chronic inflammatory diseases and a shorter life expectancy.

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“…The role of vitamin D deficiency in initiating and aggravating the course of inflammatory dermatoses is well documented; the same is true for the beneficial effects of its supplementation [ 137 , 138 , 139 ]. However, low vitamin D levels could hardly be viewed as a nutritional deficiency because “vitamin D” is in fact a group of nuclear hormones with pleiotropic actions, including immunomodulation [ 140 , 141 , 142 ]. Under favorable circumstances, all active forms of vitamin D are synthesized entirely in the body; therefore, low levels of vitamin D should be viewed as a hormonal disorder rather than nutrient deficiency [ 143 ].…”

Section: An Overview Of Diseases From the Spectrummentioning

confidence: 99%

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Śpiewak

2023

IJMS

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Researchers active in the field of inflammatory skin diseases from the spectrum of dermatitis and eczema are well aware of a considerable overlap in the clinical pictures and proposed sets of diagnostic criteria for these diseases, which can hardly be overcome through the clinical or epidemiological research. In effect, patients are included in studies based on vague and overlapping criteria, while heterogeneous study populations may, in turn, lead to non-representative outcomes and continued confusion. In this narrative review, a systematics of diseases from the spectrum of dermatitis and eczema is proposed based on the origins of causative factors and the pathomechanisms involved. Difficulties in differentiating between these diseases are discussed, and the extent to which advances in the “omics” sciences might help to overcome them is considered. Of all the “omics” research in this field, more than 90% of the published papers were devoted to atopic dermatitis, with a striking underrepresentation of other diseases from the spectrum of dermatitis and eczema, conditions which collectively exceed the rates of atopic dermatitis by far. A greater “omics” research effort is urgently needed to tackle other dermatitides, like allergic, irritant and protein contact dermatitis, as well as radiation, seborrheic, stasis or autoimmune dermatitis. Atopic dermatitis findings should be validated not only against healthy donors but also other dermatitides. A clinic-oriented approach is proposed for future “omics” studies in the field of dermatitis and eczema.

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A Pleiotropic Nuclear Hormone Labelled Hundred Years Ago Vitamin D

Abstract: This year we are celebrating 100 years of the naming of vitamin D, but the molecule is, in fact, more than one billion years old [...]

Cited by 6 publications

References 35 publications

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Vitamin D, the Sunshine Molecule That Makes Us Strong: What Does Its Current Global Deficiency Imply?

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

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