A platinum nanourchin-based multi-enzymatic platform to disrupt mitochondrial function assisted by modulating the intracellular H2O2 homeostasis

A polyoxometalate-based heterojunction nanozyme with peroxidase-mimic catalytic activity for sensitive biomolecule detection

“…As one of the most representative endogenous antioxidants in cells, GSH plays a vital part in modulating the balance between free radicals and the antioxidant defense system. [31][32][33][34] The disorders of GSH homeostasis are closely associated with such diseases as cancer, aging, neurodegenerative diseases and inammations. 33 Therefore, investigations on convenient and rational methods for GSH detection have aroused widespread concern in biochemical analysis and clinical diagnosis.…”

Metal–Organic Framework PCN-224 Integrated with Manganese Dioxide, Platinum Nanoparticles, and Glucose Oxidase for Enhanced Cancer Chemodynamic Therapy

“…40−42 For instance, catalase-mimicking platinum nanoparticles (Pt NPs) have been widely used in the construction of nanomaterials as a low-cost alternative to natural enzymes, which can decrease tumor hypoxia by catalyzing H 2 O 2 production of O 2 in situ. 26,43 Of special note is that sufficient H 2 O 2 can be generated during the oxidation of glucose by GOD to promote Fenton-like reactions. 38 Therefore, loading GOD and Pt NPs onto the same nanoplatform to fabricate a circulating nanomaterial is expected to improve therapeutic efficacy.…”

“…Glucose oxidase (GOD) is a good choice to enhance H 2 O 2 and to lower pH by oxidizing glucose into H 2 O 2 and gluconic acid. , According to the Warburg effect, tumor cells are more dependent on nutrients, such as glucose, than normal cells, and glucose plays a key role in promoting the metabolism of tumor cells. ,, Therefore, GOD-mediated glucose metabolism cannot only accelerate Fenton/Fenton-like reactions but also the starvation of tumors for starvation therapy. , However, one of the necessary conditions for GOD to oxidize glucose is O 2 , and the concentration of O 2 in most solid tumor tissues is noticeably lower than that in normal tissues. , Unfortunately, O 2 depletion caused by GOD can further exacerbate the hypoxic microenvironment . A convenient and effective strategy to overcome hypoxia has recently been introduced by generating O 2 in situ instead of transporting it, where high H 2 O 2 levels in the TME can self-produce O 2 by loading enzymes, inorganic nanocomposites, or metal oxides. − For instance, catalase-mimicking platinum nanoparticles (Pt NPs) have been widely used in the construction of nanomaterials as a low-cost alternative to natural enzymes, which can decrease tumor hypoxia by catalyzing H 2 O 2 production of O 2 in situ. , Of special note is that sufficient H 2 O 2 can be generated during the oxidation of glucose by GOD to promote Fenton-like reactions . Therefore, loading GOD and Pt NPs onto the same nanoplatform to fabricate a circulating nanomaterial is expected to improve therapeutic efficacy.…”

A double rare earth doped CD nanoplatform for nanocatalytic/starving-like synergistic therapy with GSH-depletion and enhanced reactive oxygen species generation

“…17,18 Nevertheless, the Fe 2+ -mediated catalytic reaction is inefficient under physiological neutral conditions and the weakly acidic TME (6.5-6.9) because the low conversion rate of Fe 3+ /Fe 2+ reduces the efficiency of catalytic reaction. 19 In fact, other metal ions such as Mn 2+ , Ce 3+ , Cr 4+ , and V 2+ are also found to have excellent catalytic activity. 20,21 Among them, CeO 2 exhibits high catalytic performance in various applications due to the mixed valence states of Ce 3+ and Ce 4+ and the presence of oxygen vacancies.…”