A Platelet Rich Fibrin szerepe a fogászatban és a maxillofaciális sebészetben

Major, Martin; Trimmel, Bálint; Polyák, Melinda; Kovács, D; Szabó, György

doi:10.33891/fsz.114.4.202-206

Cited by 1 publication

(2 citation statements)

References 29 publications

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“…Platelet-rich fibrin (PRF) has been studied for its potential to aid in the healing of bone defects and soft tissue. Studies have investigated the use of PRF alone or in combination with other bone substitutes [12]. Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates with simplified processing and without biochemical blood handling.…”

Section: Introductionmentioning

confidence: 99%

“…I-PRF (Injectable-PRF) is a liquid form of PRF that can be injected in a similar way to PRP, with the positive biological properties of PRF. It is centrifuged at 700 rpm for 3 min [12]. During the processing of PRF, the activation of platelets results in extensive degranulation and a significant release of cytokines, which, physiologically, can stimulate cell migration and proliferation within the fibrin matrix, initiating the healing process.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Multiple Bone Cysts Using a Platelet-Rich Fibrin and BoneAlbumin Composite Graft: A Case Report

Major,

Kivovics,

Szabó

et al. 2024

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Promising research results have been obtained on the tissue-regeneration properties of PRF (platelet-rich fibrin) in dentistry and maxillofacial surgery. PRF presumably promotes healing and accelerates ossification. In this case report, the patient had a history of Gorlin–Goltz syndrome, also called nevoid basal cell carcinoma syndrome, an autosomal dominant neurocutaneous disease that was known for many years. As a consequence, cysts were detected in both the mandible and maxilla. We performed decompression on this 37-year-old patient, followed by a cystectomy on an extensive lesion in the right angle of the mandible. One cyst from each side of the body mandible and one from the maxilla were completely enucleated, as determined using an intraoral exploration. The resulting bone defect was filled with a composite graft composed of a mixture of A-PRF and a serum albumin-coated bone allograft (BoneAlbumin). The wound was then covered with a PRF membrane. The surgical sites were closed per primam. The postoperative period was uneventful. Biopsies were performed after three and six months of healing for histological micromorphometry analyses. Dental implants were placed at the sampling site. Three months after the implantation, the ossified implants were fitted with superstructures. To date, no complications have appeared with the bone augmentation. The authors interpret from the findings that the combination of A-PRF and BoneAlbumin can be validated as a prosperous bone substitute. It can be safely implanted after a 3-month ossification period.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%