A plasmonic nanorod that walks on DNA origami

Zhou, Chao; Duan, Xiaoyang; Liu, Na

doi:10.1038/ncomms9102

Cited by 287 publications

(326 citation statements)

References 39 publications

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“…Furthermore, nucleic acids-both DNA and RNAare well known for their ability to bind to and sense small molecules (68,69), thus providing direct mechanisms to "read" the chemical environment. Nucleic acid nanotechnology has also been applied to control chemical synthesis (70)(71)(72); to control the arrangement (and rearrangement) of metal nanoparticles, quantum dots, carbon nanotubes, proteins, and other molecules (73)(74)(75)(76)(77); and to control the activity of enzymes and protein motors (78)(79)(80). Much as genetic regulatory networks and other biochemical feedback networks control chemical and molecular functions within biological cells, it is conceivable that nucleic acid dynamical systems could serve as the information processing and control networks within complex synthetic or- .…”

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confidence: 99%

Enzyme-free nucleic acid dynamical systems

Srinivas

Parkin

Seelig

et al. 2017

Science

306

298

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Chemistries exhibiting complex dynamics-from inorganic oscillators to gene regulatory networks-have been long known but cannot be reprogrammed at will because of a lack of control over their evolved or serendipitously found molecular building blocks. Here we show that information-rich DNA strand displacement cascades could be systematically constructed to realize complex temporal trajectories specified by an abstract chemical reaction network model. We codify critical design principles in a compiler that automates the design process, and demonstrate our approach by building a novel DNA-only oscillator. Unlike biological networks that rely on the sophisticated chemistry underlying the central dogma, our test tube realization suggests that simple Watson-Crick base pairing interactions alone suffice for arbitrarily complex dynamics. Our result establishes a basis for autonomous and programmable molecular systems that interact with and control their chemical environment.

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mentioning

confidence: 99%

Enzyme-free nucleic acid dynamical systems

Srinivas

Parkin

Seelig

et al. 2017

Science

306

298

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“…However, the power of circular dichroism (CD) spectroscopy is apparent in the strong, sharp chiroptical response of the Au-Fe nanohelix metafluid. At a peak wavelength of 690 nm, it exhibits a molar CD = ~14×10 9 o ·M -1 ·cm -1 , stronger than that observed for other chiral assembled plasmonic systems 11,[42][43][44] . Complex fluids, such as blood, whose rheology we set out to measure generally show no measurable chiroptical response of their own in this spectral region 45 .…”

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confidence: 65%

Active Nanorheology with Plasmonics

et al. 2016

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Nanoplasmonic systems are valued for their strong optical response and their small size. Most plasmonic sensors and systems to date have been rigid and passive. However, rendering these structures dynamic opens new possibilities for applications. Here we demonstrate that dynamic plasmonic nanoparticles can be used as mechanical sensors to selectively probe the rheological properties of a fluid in situ at the nanoscale and in microscopic volumes. We fabricate chiral magneto-plasmonic nanocolloids that can be actuated by an external magnetic field, which in turn allows for the direct and fast modulation of their distinct optical response.The method is robust and allows nanorheological measurements with a mechanical sensitivity of ~0.1 cP, even in strongly absorbing fluids with an optical density of up to OD~3 (~0.1% light transmittance) and in the presence of scatterers (e.g. 50% v/v red blood cells). KEYWORDS.Magneto-plasmonics, chiral plasmonics, chiroptical switch, nanorheologyThe resonant optical field enhancement in plasmonic nanostructures is of interest in research disciplines ranging from sensing to energy conversion, and is the basis for modern advances in metamaterials and the associated capabilities in shaping electromagnetic fields 1-3 .The scope of potential applications of nanoplasmonic structures is greatly extended by tailoring the nanostructure, for instance to shift the resonance frequency while keeping the overall size of the nanoparticle small 4-7 , or by incorporating diverse functionalities, such as magnetic 8 , chiral 9 , and electrical 10 . Recent fabrication advances have also allowed the programmatic growth of nanoparticles that lack mirror symmetry [11][12][13][14][15] . Such chiral nanoparticles mimic their molecular counterparts by exhibiting optical activity, but with One particularly challenging application is the measurement of rheological properties in complex fluids. Such systems contain a mixture of multiple phases; for instance, many biological fluids contain solids consisting of isolated microparticles or a network of macromolecules suspended in a fluid phase 20 . Because of the solid phase, macroscopic rheological measurements will generally show non-Newtonian viscoelastic behavior even if the liquid phase is a simple Newtonian fluid 21 . For instance, the viscosity of blood plasma is a crucial indicator for clinical diagnoses 22,23 , but cannot be determined in whole blood due to the presence of leukocytes (10-15 µm) and erythrocytes (6-8 µm) 24,25 . Furthermore, the solid phase in complex fluids, such as blood cells, contributes to absorption and scattering which complicate optical measurements.By combining multiple materials and shape control, we here introduce chiral magnetoplasmonic structures that can be actuated in solution. Since the chiroptical spectrum depends on the alignment of the chiral structure (Figure 1a), we can achieve chiroptical switching and exploit it for nanorheological measurements using picomolar probe concentrations. The scheme works by using...

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“…And then rolling the 2D sheets to obtain the 3D AuNP helices, the diameter and axial length, as well as the pitch of the 3D AuNP helices could be tuned by rectangular DNA origami template and the AuNP chain number on the origami. A latest particularly outstanding study published on Nature by Zhou and co-workers [47] deserves to be mentioned. In an active plasmonic system, a gold nanorod can carry out directionally and progressively walking on DNA origami step by step, which triggers a series of conformational changes and activates subsequent near-field interaction changes, giving an optically immediate spectral response that can be read out.…”

Section: D or 3d Scaffold With Well-designed Binding Sitesmentioning

confidence: 97%

Applications of DNA Nanotechnology in Synthesis and Assembly of Inorganic Nanomaterials

Yang

Wei

et al. 2016

Chin. J. Chem.

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In addition to its inherited genetic function, DNA is one of the smartest and most flexible self-assembling nanomaterials with programmable and predictable features, for which, more and more scientists combine DNA with nanomaterials and put them into designing, synthesizing and assembling. In this review, four modes of action of DNA molecules are introduced in a figurative and intuitive way, based on the four different roles it plays in synthesis and assembly of nanomaterials: (a) smart linkers to guide nanoparticle assembly, (b) 2D or 3D scaffold with well-designed binding sites, (c) nucleation sites to directly facilitate Au/Pd/Ag/Cu nanowires, nanoparticles, nanoarrays and (d) serving as capping agents to prevent crystal growth, and control size and morphology. To be sure, this state-of-the-art combination of functional DNA molecules and inorganic nanomaterials greatly encouraged step towards the development of analytical science, life science, environmental science, and other promising field they can address. DNA-guided nanofabrication will eventually exceed expectations far beyond our scope in the near future.

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A plasmonic nanorod that walks on DNA origami

Cited by 287 publications

References 39 publications

Enzyme-free nucleic acid dynamical systems

Enzyme-free nucleic acid dynamical systems

Active Nanorheology with Plasmonics

Applications of DNA Nanotechnology in Synthesis and Assembly of Inorganic Nanomaterials

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