1995
DOI: 10.1016/0166-6851(95)00075-c
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A Plasmodium falciparum protein kinase with two unusually large kinase inserts

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Cited by 22 publications
(9 citation statements)
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“…Alternatively, the extremely charged repeat structures present in the C-terminus of the PfMAP gene product may alter the migration behaviour of the protein during SDS-PAGE. A 30 kDa reduction of the apparent molecular mass, probably caused by the amino acid content of the protein, was observed in the PfPK1 kinase (Kappes et al, 1995).…”
Section: Discussionmentioning
confidence: 94%
“…Alternatively, the extremely charged repeat structures present in the C-terminus of the PfMAP gene product may alter the migration behaviour of the protein during SDS-PAGE. A 30 kDa reduction of the apparent molecular mass, probably caused by the amino acid content of the protein, was observed in the PfPK1 kinase (Kappes et al, 1995).…”
Section: Discussionmentioning
confidence: 94%
“…Their position either in a cluster (composed of PfPK6 and Pfcrk-5) that is intermediate between the CDK and the MAPK groups, or in a cluster (composed of Pfcrk-4 and uncharacterized MAL13P1.196) at the base of the CDK/MAPK/GSK3 branch, is consistent with these early observations. Three GSK3-related kinases, two of which [PF08_0044 and PFC0525c] have been characterised previously [36,37], form a cluster within the CMGC group. Four additional enzymes form another cluster that includes human Clk1, one of which is a previously described LAMMER-related kinase [PF14_0431] [38].…”
Section: Resultsmentioning
confidence: 99%
“…First, the catalytic domain is larger in Pfmap-2 than in other members of the MAPK family, because of the presence of three insertions in poorly conserved regions (residues 263-282, 328 -337, and 348 -364). Similar but much longer atypical insertions, whose functional significance is unknown, have been found in another P. falciparum protein kinase (21). Unlike Pfmap-1 and Pfcrk-1 (a P. falciparum CDK-related kinase) (13), Pfmap-2 does not possess a large extension with repeated amino acid motifs at its amino or carboxyl terminus; the region upstream of the Pfmap-2 catalytic domain, however, is larger than that of most members of the MAPK family.…”
Section: Isolation Of a P Falciparum Gene Encoding A Protein Relatedmentioning
confidence: 92%