A plasma proteomic signature links secretome of senescent monocytes to aging- and obesity-related clinical outcomes in humans
Bradley Olinger,
Reema Banarjee,
Amit Dey
et al.
Abstract:Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence associated with diverse clinical traits in humans to facilitate future non-invasive assessment of individual senescence burden and efficacy testing of novel senotherapeutics. Using a novel nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) in monocytes and examined these proteins in plasma samples (N = 1060) from … Show more
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