A Plant Viral “Reinitiation” Factor Interacts with the Host Translational Machinery

Park, Hyun Sook; Himmelbach, Axel; Browning, Karen S.; Höhn, Thomas; Ryabova, Lyubov A.

doi:10.1016/s0092-8674(01)00487-1

Cited by 154 publications

(238 citation statements)

References 52 publications

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“…eIF3 was implicated at every step of translation initiation, including 43S and 48S preinitiation complex formation assembly, AUG start codon recognition, and reinitiation of translation, when ribosomes terminating translation of the leader uORF resume scanning and reinitiate at a further downstream ORF on the same mRNA (Park et al, 2001;Kim et al, 2004;Pöyry et al, 2007;Schepetilnikov et al, 2013).…”

Section: Eif3 and Polysomes Are Platforms For Tor Phosphorylation Eventsmentioning

confidence: 99%

“…This model helps explain why reinitiation is precluded after a long elongation event, when all factors gradually dissociate from the translating ribosome before the termination step. eIF3 has been suggested as a ribosome-associated RPF in yeast (Cuchalová et al, 2010;Munzarová et al, 2011) and plants (Park et al, 2001;Schepetilnikov et al, 2013), while eIF4F, elongation factor 2, and DENR-MCT-1 promote reinitiation in mammals (Pöyry et al, 2004;Skabkin et al, 2013;Schleich et al, 2014).…”

Section: Role Of Tor In Regulation Of Translation Of Specific Mrnas Mmentioning

confidence: 99%

“…TAV can interact with the cell translation machinery via the 60S ribosomal subunit, where it targets at least two ribosomal proteins, eL18 and eL24 (Park et al, 2001). …”

Section: Virus-activated Reinitiation After Long Orf Translationmentioning

confidence: 99%

“…TAV binds and activates TOR (TOR-P). TAV retains eIF3/RISP on the translating ribosome during the long elongation event, likely by transferring to the rear side of the 60S subunit through association with eL18 or eL24 in the 60S subunit (Park et al, 2001;Thiébeauld et al, 2009). TOR-P associates with polysomes, where it maintains high RISP phosphorylation status.…”

Section: -Utr Motifs That Are Controlled By Tor In Animalsmentioning

confidence: 99%

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Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants

2017

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Protein synthesis is an intricate, energy-demanding, and tightly controlled process that plays a fundamental role in cell growth, proliferation, and differentiation. The target of rapamycin (TOR) protein kinase integrates stress-, nutrient-, and energy-related signals to optimize protein synthesis outputs. In mammals, TOR is a main controller of capped mRNA translation; how TOR participates in translation initiation in plants is unclear, but active TOR is required for regulation of translation of mRNA with 59-untranslated region (59-UTR) upstream open reading frames (uORFs)-known translation regulatory elements in eukaryotes. Recent data implicates diverse signals such as stress, hormones, and metabolites in regulation of TOR signal transduction pathways and, thus, in response to environmental stress. Here, we review current knowledge of plant TOR complex composition and activation, and its function in translation, compiling data on downstream processes that are under stringent control of TOR in mammals but not yet investigated in plants.Plants have evolved various adaptation mechanisms to ensure their optimal growth, with plant development and behavior being strongly responsive to various external and internal stimuli. By monitoring their environment, plants trigger signal transduction cascades in order to regulate downstream cellular processes, mainly via protein synthesis-a major energy-consuming process (Buttgereit and Brand, 1995). The TOR protein kinase integrates extracellular signals (hormones, biotic and abiotic stresses, growth factors) together with intracellular nutrient availability and energy status to control protein synthesis and other anabolic processes if conditions are favorable, and represses catabolic processes such as autophagy (Albert and Hall, 2015). The past 10 years has boosted research on plant TOR complex composition, highlighted TOR upstream signals and downstream targets, and revealed an interplay between TOR signaling and hormonal, stress, and other pathways in photosynthetic organisms. We are beginning to understand how TOR is activated, and how it controls many cellular processes, such as transcription, translation, and autophagy. Here, we give an overview of recent results on the role of TOR in plant translation control and draw the reader's attention to future questions to address. In plants, inactivation of TOR correlates with a decrease in total polysomal levels (Deprost et al., 2007;Schepetilnikov et al., 2011Schepetilnikov et al., , 2013, strongly suggesting a role for TOR in plant translation. Although a role for TOR in global translation in plants has been documented, the players and mechanisms used to influence different steps of translation initiation -the step most controlled by TOR in mammals-are only starting to emerge. Here, we summarize the current state of knowledge of specific plant translation initiation mechanisms that are controlled by 59-UTR elements of mRNAs and discuss regulation of these mechanisms by TOR/S6 kinase 1 (S6K1) signaling. Examples where TOR re...

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Section: Eif3 and Polysomes Are Platforms For Tor Phosphorylation Eventsmentioning

confidence: 99%

Section: Role Of Tor In Regulation Of Translation Of Specific Mrnas Mmentioning

confidence: 99%

“…TAV can interact with the cell translation machinery via the 60S ribosomal subunit, where it targets at least two ribosomal proteins, eL18 and eL24 (Park et al, 2001). …”

Section: Virus-activated Reinitiation After Long Orf Translationmentioning

confidence: 99%

Section: -Utr Motifs That Are Controlled By Tor In Animalsmentioning

confidence: 99%

See 2 more Smart Citations

Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants

2017

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“…For example, eIF3e binds to P56, an interferon-induced protein that inhibits protein synthesis (46). eIF3g binds to PAIP, a PABP-binding protein that stimulates initiation (47); in addition, plant eIF3g binds to TAV, required for shunting of the 40S initiation complex during scanning/reinitiation (48). eIF3f binds to Atrogina/MAFbx, a ubiquitin E3 ligase that degrades the subunit during muscle atrophy (49).…”

Section: Regulation Of Eif3 Is Important In Controlling Cell Prolifermentioning

confidence: 99%

Regulation of protein synthesis and the role of eIF3 in cancer

Hershey¹

2010

Braz J Med Biol Res

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Reinitiation

2004

Encyclopedic Dictionary of Genetics, Genomics and Proteomics

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A Plant Viral “Reinitiation” Factor Interacts with the Host Translational Machinery

Cited by 154 publications

References 52 publications

Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants

Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants

Regulation of protein synthesis and the role of eIF3 in cancer

Reinitiation

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