A plant‐unique ESCRT component, FYVE4, regulates multivesicular endosome biogenesis and plant growth

Liu, Chuanliang; Zeng, Yonglun; Li, Hongbo; Yang, Chao; Xu, Min; Xiao, Zhidan; Chen, Tongsheng; Li, Baiying; Cao, Wenhan; Jiang, Liwen; Otegui, Marisa S.; Gao, Caiji

doi:10.1111/nph.17358

Cited by 24 publications

(18 citation statements)

References 76 publications

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“…SNF7 typically oligomerizes into spirals at the ILV budding site and its retention at the concatenated vesicles in plants might possibly form a diffusion barrier to prevent cargo protein escape (Buono et al, 2017). Furthermore, SNF7 is stabilized at the endosomal membrane by FYVE4, a novel FYVE-domain containing plant-specific protein (Liu et al, 2021). Significant crosstalk between the ESCRT function, phytohormonal, and stress response pathways are starting to emerge (Ge et al, 2019;Li et al, 2019;Xiao et al, 2020).…”

Section: Post-golgi Traffic Via Maturation Of Endomembrane Organellesmentioning

confidence: 99%

Molecular mechanisms of endomembrane trafficking in plants

et al. 2021

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Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus, early and recycling endosomes, multivesicular body (MVB) or late endosome (LE), lysosome/vacuole, and plasma membrane (PM). Even although historically plants have given rise to cell biology, our understanding of membrane trafficking has mainly been shaped by the much more studied mammalian and yeast models. Whereas organelles and major protein families that regulate endomembrane trafficking are largely conserved across all eukaryotes, exciting variations are emerging from advances in plant cell biology research. In this review, we summarize the current statet of knowledge on plant endomembrane trafficking, with a focus on four distinct trafficking pathways: ER-to-Golgi transport, endocytosis, trans-Golgi network-to-vacuole transport, and autophagy. We acknowledge the conservation and commonalities in the trafficking machinery across species, with emphasis on diversity and plant-specific features. Understanding the function of organelles and the trafficking machinery currently non-existent in well-known model organisms will provide great opportunities to acquire new insights into the fundamental cellular process of membrane trafficking.

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Section: Post-golgi Traffic Via Maturation Of Endomembrane Organellesmentioning

confidence: 99%

Molecular mechanisms of endomembrane trafficking in plants

et al. 2021

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“…However, we were able to find ISTL1 (Goodman et al, 2021 ) in A. thaliana and yeast, but not in these bryophytes or mammal ( Figure 2B and Supplementary Table 2 ). Specially, VPS37 (component of ESCRT-I) (Okumura et al, 2013 ), LIP5 (positive regulator of VPS4/SKD1) (Buono et al, 2016 ), and FYVE4 (affect the connection of ESCRT-III and VPS4) (Liu et al, 2021 ) are absent in hornwort. More interestingly, as a suppressor of FREE1 (Gao et al, 2014 ), RESURRECTION1 (RST1) (Zhao et al, 2019 ) only exists in S. fallax, S. magellanicum and M. polymorpha , which indicates that this protein may have special functions in these bryophytes ( Figure 2B ).…”

Section: Changes In the Molecular Toolkit Controlling Vacuole Biogene...mentioning

confidence: 99%

Vacuoles in Bryophytes: Properties, Biogenesis, and Evolution

et al. 2022

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Vacuoles are the most conspicuous organelles in plants for their indispensable functions in cell expansion, solute storage, water balance, etc. Extensive studies on angiosperms have revealed that a set of conserved core molecular machineries orchestrate the formation of vacuoles from multiple pathways. Usually, vacuoles in seed plants are classified into protein storage vacuoles and lytic vacuoles for their distinctive morphology and physiology function. Bryophytes represent early diverged non-vascular land plants, and are of great value for a better understanding of plant science. However, knowledge about vacuole morphology and biogenesis is far less characterized in bryophytes. In this review, first we summarize known knowledge about the morphological and metabolic constitution properties of bryophytes' vacuoles. Then based on known genome information of representative bryophytes, we compared the conserved molecular machinery for vacuole biogenesis among different species including yeast, mammals, Arabidopsis and bryophytes and listed out significant changes in terms of the presence/absence of key machinery genes which participate in vacuole biogenesis. Finally, we propose the possible conserved and diverged mechanism for the biogenesis of vacuoles in bryophytes compared with seed plants.

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“…Microscopy images were processed using the ZEN imaging software (Zeiss). The colocalization ratio of GFP-FREE1 and mCherry-ATG8f was quantified by using ImageJ software with a Pearson-Spearman correlation (PSC) plugin as described previously [48,49].…”

Section: Laser Scanning Confocal Microscope Observationmentioning

confidence: 99%

Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency

Zhang

Xiao

Liu

et al. 2021

IJMS

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Multivesicular body (MVB)-mediated endosomal sorting and macroautophagy are the main pathways mediating the transport of cellular components to the vacuole and are essential for maintaining cellular homeostasis. The interplay of these two pathways remains poorly understood in plants. In this study, we show that FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING 1 (FREE1), which was previously identified as a plant-specific component of the endosomal sorting complex required for transport (ESCRT), essential for MVB biogenesis and plant growth, can be transported to the vacuole for degradation in response to iron deficiency. The vacuolar transport of ubiquitinated FREE1 protein is mediated by the autophagy pathway. As a consequence, the autophagy deficient mutants, atg5-1 and atg7-2, accumulate more endogenous FREE1 protein and display hypersensitivity to iron deficiency. Furthermore, under iron-deficient growth condition autophagy related genes are upregulated to promote the autophagic degradation of FREE1, thereby possibly relieving the repressive effect of FREE1 on iron absorption. Collectively, our findings demonstrate a unique regulatory mode of protein turnover of the ESCRT machinery through the autophagy pathway to respond to iron deficiency in plants.

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A plant‐unique ESCRT component, FYVE4, regulates multivesicular endosome biogenesis and plant growth

Cited by 24 publications

References 76 publications

Molecular mechanisms of endomembrane trafficking in plants

Molecular mechanisms of endomembrane trafficking in plants

Vacuoles in Bryophytes: Properties, Biogenesis, and Evolution

Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency

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