A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review

Alorku, Kingdom; Manickam, Manoj; Yuan, Aihua

doi:10.1039/d0ra08529d

Cited by 33 publications

(17 citation statements)

References 225 publications

(189 reference statements)

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“…Furthermore, apart from biomedical applications, many other remarkable and diverse uses of Hap have also been reported. 10,11 With regard to these particular applications, the development of novel approaches to synthesize Hap using various Ca and P sources is now a vital task for researchers. Nevertheless, to expand the biomaterial research eld, a signicant number of procedures have been developed by scientists to synthesize Hap, such as wet chemical precipitation, 1,12,13 electrochemical methods, 14,15 solid-state reactions, 16 hydrothermal, 17,18 microemulsion, 19 sol-gel 20 and microwave irradiation 21 methods and so on.…”

Section: Introductionmentioning

confidence: 99%

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UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, apart from biomedical applications, many other remarkable and diverse uses of Hap have also been reported. 10,11 …”

Section: Introductionmentioning

confidence: 99%

UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

et al. 2021

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“…33 Besides that, hydroxyapatite can also be produced from natural sources such as mammalian bones, 41 egg shells 46 and plant sources. 4,45 Each of these methods controls the sizes, chemical composition, crystallinity and morphology of synthesized hydroxyapatite, and those properties influence the biocompatibility, bioactivity, mechanical strength and biological properties. Figure 2 summarizes the several methods used to synthesize the synthetic hydroxyapatite.…”

Section: Synthesis Of Synthesized Hydroxyapatitementioning

confidence: 99%

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Halim¹,

Hussein²,

Kandar

2021

IJN

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Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.

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“…The interests for Ag-doped HA synthesis are related to the composition of dopant in the nanocomposite–due to its toxicity at a certain level–and to the effectiveness of the synthesis procedure, cost, and materials characteristics [ 10 ]. One of the critical developments is to minimize the use of hazardous chemicals by the green synthesis approach, either in the synthesis of AgNPs or synthesis of HA.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Antibacterial Nanocomposite of Silver Nanoparticle-Doped Hydroxyapatite Utilizing Curcuma longa Leaf Extract and Land Snail (Achatina fulica) Shell Waste

Fatimah

Hidayat

Purwiandono

et al. 2022

JFB

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Preparation of green synthesized silver nanoparticle (AgNPs)-doped hydroxyapatite (Ag/HA) utilizing Curcuma longa leaf extract and land snail (Achatina fulica) shell waste was performed. Physicochemical characteristics and antibacterial activity of Ag/HA composite as a function of Ag content was studied. Instrumental analysis such as XRD, SEM-EDX, TEM, and XPS were employed to characterize the nanocomposites. The physicochemical study revealed the maintained porous structure of HA after Ag immobilization, and from TEM analyses, it was found that the distributed spherical particles are associated with the dispersed Ag and have a particle diameter of around 5–25 nm. Antibacterial activity of the nanocomposite was evaluated against Escherichia coli, Staphylococcus aureus, Kliebsiella pneumonia, and Streptococcus pyogenes. The results showed that the varied Ag content (1.0; 1.6; and 2.4% wt) influenced the nanoparticle distribution in the nanocomposite and enhanced the antibacterial feature.

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A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review

Abstract: Plant-mediated sythesis of nanostructured hydroxyapatite for multifunctional biomedical applications.

Cited by 33 publications

References 225 publications

UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Green Synthesis of Antibacterial Nanocomposite of Silver Nanoparticle-Doped Hydroxyapatite Utilizing Curcuma longa Leaf Extract and Land Snail (Achatina fulica) Shell Waste

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