A Placebo-Controlled Trial of Maintenance Therapy with Fluconazole after Treatment of Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome

Abstract

In patients with AIDS, silent persistent infection is common after clinically successful treatment for cryptococcal meningitis. Maintenance therapy with fluconazole is highly effective in preventing recurrent cryptococcal infection.

Meningitis por Cryptococcus neoformans en niños y adolescentes infectados por virus de la inmunodeficiencia humana

“…En todos se hizo terapia de mantenimiento con fluconazol, ya que sin esta medida de profilaxis secundaria se observa una alta tasa de recaídas 28,31 .…”

Disseminated Cryptococcosis Presenting with Adrenal Insufficiency and Meningitis: Resistant to Prolonged Antifungal Therapy but Responding to Bilateral Adrenalectomy.

“…Intravenous amphotericin B with or without flueytosine, is usually the standard form of therapy (18). Recently, an increasing number of reports have been published concerning AIDS-associated cryptococcal meningitis (9)(10)(11)(12)(19)(20)(21)(22). Fluconazole is an effective alternative to amphotericin B for the primary and maintenance treatment of cryptococcal meningitis (22).…”

Opportunistic Infections in HIV‐Infected Patients

“…Secondary prophylaxis: Fluconazole at a dose of 200 mg/ day reportedly is more effective than either placebo or amphotericin B given intravenously at a dosage of l mg/ kg once a week in the secondary prophylaxis of cryptococcal infection in AJDS patients (67,68) .…”