A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children

Duchowny, Michael; Pellock, John M.; Graf, Wolfgang; Billard, C.; Gilman, Jamie T.; Casale, Eugene J.; Womble, G.; Risner, Marcus E.; Manasco, Penelope K.

doi:10.1212/wnl.53.8.1724

Cited by 120 publications

(73 citation statements)

References 31 publications

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“…There is one study 69 with class I evidence that evaluated the efficacy of lamotrigine versus placebo in 199 children aged 2 to 16 years. The lamotrigine target doses varied according to the type of AED the child was taking at the time of randomization: 1 to 3 mg/kg in the presence of valproic acid only, 1 to 5 mg/kg if an enzyme inducing AED (phenytoin, carbamazepine, phenobarbital) in combination with valproic acid, and 5 to 15 mg/kg if the child was on enzyme inducing AED only.…”

Section: Treatment Of Refractory Epilepsy In Children Question 4: Whmentioning

confidence: 99%

Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy [RETIRED]

et al. 2004

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Abstract-Objective:To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane library for relevant articles from 1987 until March 2003. Results: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. Gabapentin can be effective for the treatment of mixed seizure disorders, and gabapentin, lamotrigine, oxcarbazepine, and topiramate for the treatment of refractory partial seizures in children. Limited evidence suggests that lamotrigine and topiramate are also effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox Gastaut syndrome. Conclusions: The choice of AED depends upon seizure and/or syndrome type, patient age, concomitant medications, AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes where more evidence is necessary.

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Section: Treatment Of Refractory Epilepsy In Children Question 4: Whmentioning

confidence: 99%

Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy [RETIRED]

et al. 2004

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“…Some of the medications listed in Table 10.6 have been tested in monotherapy, but most have been tested as adjunctive treatment for partial onset seizures. Figure 10.2 illustrates the efficacy rates for newer antiepileptic drugs as adjunctive therapy in children [34][35][36][37][38]. While they are tested as adjunctive therapy, in order to gain regulatory approval, every medication that has ever shown efficacy for treatment of partial-onset seizures as adjunctive therapy, has been effective when used as monotherapy.…”

Section: Partial-onset Seizuresmentioning

confidence: 99%

Therapeutic Efficacy of Antiepileptic Drugs

Wheless

2012

Epilepsy in Children and Adolescents

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“…28 Lamotrigine has been shown to be effective as add-on therapy of refractory partial and generalized seizure in children. 29,30 This drug is considered to have a broad spectrum of action, analogous to valproic acid, effective in partial seizures as well as a variety of generalized epilepsies, including absence seizures and myoclonic seizures. It has been proven effective in Lennox-Gastaut syndrome and is commonly used in childhood absence epilepsy as well.…”

Section: Lamotrigine (Lamictal®)mentioning

confidence: 99%

New generation anticonvulsants for the treatment of epilepsy in children

Donner

Snead

2006

NeuroRX

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Summary:In the last 12 years, 10 new anticonvulsants have been approved by the U.S. Food and Drug Administration and, as a result, the treatment options for children and adults with epilepsy have been expanded considerably. These new generation antiepileptic drugs offer equal efficacy with improved tolerability, pharmacokinetic properties, and side effect profiles compared with the traditional drugs. With many new medications available, the clinician treating children with epilepsy must be well versed in the application of these drugs to their patient population. This manuscript will review the indications, mechanism of action, pharmacokinetics, adverse effects, and dosing of the new generation of anticonvulsant medications.

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A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children

Abstract: Lamotrigine was effective for the adjunctive treatment of partial seizures in children and demonstrated an acceptable safety profile.

Cited by 120 publications

References 31 publications

Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy [RETIRED]

Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy [RETIRED]

Therapeutic Efficacy of Antiepileptic Drugs

New generation anticonvulsants for the treatment of epilepsy in children

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