A placebo‐controlled trial of an oral capsaicin load in patients with functional dyspepsia

Führer, Martina; Vogelsang, Harald; Hammer, Johann

doi:10.1111/j.1365-2982.2011.01766.x

Cited by 35 publications

(34 citation statements)

References 55 publications

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“…Moreover, it has been previously observed that the TRP1 channel could also be involved in gastric motility regulation. Studies with capsaicin in FD patients showed an increase in hypersensitivity and dyspeptic upper gut symptoms [57,58,59,60,61]. However, the known hypersensitivity in the subjects was not a predictor for the symptoms and their intensity [57].…”

Section: Visceral Hypersensitivitymentioning

confidence: 99%

Gastroduodenal Mechanisms Underlying Functional Gastric Disorders

Carbone¹,

Tack²

2014

Dig Dis

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Functional dyspepsia (FD), a disorder thought to originate from the gastroduodenum, is one of the most prevalent functional gastrointestinal disorders. In this review, we focused on gastroduodenal mechanisms involved in the pathophysiology of FD. The roles of impaired gastric accommodation, delayed gastric emptying, hypersensitivity to gastric distention and to luminal agents, altered mucosal integrity, low-grade inflammation and psychological stress are reviewed. The underlying pathophysiology in FD is probably multifactorial, involving a combination of several of these factors, ultimately leading to symptom pattern and severity.

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Section: Visceral Hypersensitivitymentioning

confidence: 99%

Gastroduodenal Mechanisms Underlying Functional Gastric Disorders

Carbone¹,

Tack²

2014

Dig Dis

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“…TRP vanilloid type 1 (TRPV1) is a polymodal nociceptor on GI afferent neurons and is the specific sensor for capsaicin. Based on oral capsaicin capsule titration, the majority of adults with FD demonstrate visceral chemosensitivity involving TRPV1 pathways [67][68][69] . Repeated ingestion of capsaicin in healthy volunteers initially increases symptoms, but after 4 wk decreases symptoms through desensitization of both chemo-and mechanoreceptors [70] .…”

Section: Mechanisms Of Hypersensitivitymentioning

confidence: 99%

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Rosen

Cocjin

Schurman

et al. 2014

WJGPT

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Functional gastrointestinal disorders (FGID) are common clinical syndromes diagnosed in the absence of biochemical, structural, or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age, geography, and culture. Etiology of abdominal pain associated FGIDs, including functional dyspepsia (FD), remains incompletely understood, but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD, with focus on pediatric data when available, and provides a summary of potential therapeutic targets. Visceral sensitivity and intestinal electromechanical function both are demonstrated to be altered in some FD patients and are potential targets for treatment. Limited studies in pediatric FD are available, but available evidence supports adult data that targeting visceral hypersensitivity and electromechanical dysfunction is warranted, particularly in the context of the biopsychosocial model. Future studies in pediatrics are needed to determine optimal therapy and appropriate patient application.Rosen JM, Cocjin JT, Schurman JV, Colombo JM, Friesen CA. Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia. World

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“…A more recent report suggested that oral capsaicin load of 0.75 mg induced dyspeptic symptoms in half of subjects with FD but negligible in placebo 41. Capsaicin, a well-known compound present in chili is a potent activator of transient receptor potential ion channel of the vanilloid type 1 which has been recognized to play an important role in visceral nociception.…”

Section: Chemical Hypersensitivity Testmentioning

confidence: 99%

Investigating Functional Dyspepsia in Asia

Lee

Chua²

2012

J Neurogastroenterol Motil

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The diagnosis of functional dyspepsia (FD) is challenging since it depends largely on symptoms which are often heterogeneous and overlapping. This is particularly so in Asia with many different cultures and languages. Symptom-based diagnosis of FD based on Rome III criteria has not been fully validated and it may not be suitable in some Asian populations. Clinicians often assume that investigations in FD are not rewarding and physiological tests are often not available unless in the research setting. Investigation of alarm features and role of Helicobacter pylori in FD remain controversial but experts agreed that both should be tested. Physiological tests including gastric accommodation and chemical hypersensitivity tests are underutilized in Asia and available studies were few. While experts do not recommend routine clinical use of gastric accommodation tests but they agree that these tests can be advocated if clinically indicated. Empiric therapeutic trial is not currently a diagnostic option. The pathogenesis of FD is still poorly understood and there is a substantial placebo response. As a conclusion, a diagnosis of FD is challenging especially so in the context of Asia and despite the limitations of available physiological tests experts agreed that these tests can be advocated if and when clinically indicated.

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A placebo‐controlled trial of an oral capsaicin load in patients with functional dyspepsia

Abstract: Half of functional dyspepsia patients had chemical hypersensitivity, determined with an oral capsaicin load. Placebo response was negligible. The results of the capsaicin test were not associated with specific dyspepsia symptoms or Rome subgroups.

Cited by 35 publications

References 55 publications

Gastroduodenal Mechanisms Underlying Functional Gastric Disorders

Gastroduodenal Mechanisms Underlying Functional Gastric Disorders

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Investigating Functional Dyspepsia in Asia

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