A Placebo-Controlled, Double-Blind Crossover Study of Naltrexone Hydrochloride in Outpatients with Normal Weight Bulimia

Mitchell, James E.; Christenson, Gary A.; Jennings, Jeffrey; Huber, Marguerite; Thomas, Brenda; Pomeroy, Claire; Morley, John

doi:10.1097/00004714-198904000-00004

Cited by 99 publications

(30 citation statements)

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“…There were however several methodological limitations to this study. Mitchell et al [1989a] carried out openlabel trials in women with BN who had failed to respond to imipramine and found that 46% had a complete remission during a second trial, most often with a monoamine oxidase inhibitor or fluoxetine. The sample in this study though consisted of just 15 subjects.…”

Section: Long-term Antidepressant Treatmentmentioning

confidence: 99%

Drug Treatment for Bulimia nervosa

Freeman

1998

Neuropsychobiology

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Section: Long-term Antidepressant Treatmentmentioning

confidence: 99%

Drug Treatment for Bulimia nervosa

Freeman

1998

Neuropsychobiology

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“…The role of opioids in bulimia is unclear because discrepant Findings have been described in the literature. In fact, naloxone has been found to reduce food intake in bulimic women [I], and an open chronic trial with naltrexone has shown improve ment in frequency and duration of binge-eating and in fre quency of purging [32], In contrast, a double-blind trial did not find significant changes in binge/vomit frequency in naltrexone-treated bulimic women [7], Further studies are needed to clarify the role of en hanced (3-endorphin secretion in the pathophysiology of bulimia nervosa. …”

Section: Acth Cortisol and (3-endorphin In Bulimiamentioning

confidence: 99%

“…A possible connection between eating disorders and endoge nous opioids has been proposed in various animal studies [ 1 ] and has been both confirmed [2][3][4][5], and doubted [6,7] in studies of humans. At present, endogenous opioid activity in bulimia is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Circadian Variations in Plasma ACTH, Cortisol and β-Endorphin Levels in Normal-Weight Bulimic Women

Vescovi¹,

Rastelli²,

Volpi³

et al. 1996

Neuropsychobiology

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In order to establish possible alterations in the secretory patterns of adrenocorticotropic hormone (ACTH), cortisol and/or β-endorphin in bulimia nervosa, the circadian fluctuations of these hormones were evaluated in blood samples taken at 1-hour intervals over 24 h. Eleven bulimic women with normal body weight and 8 weight- and age-matched normal controls were tested during the follicular phase (days 6-8) of normal menstrual cycles. All women were hospitalized for bulimia or for checkup examinations and were tested 3 days after hospital admission. Both normal and bulimic women showed maximal ACTH, cortisol and β-endorphin levels at 08.00 h, with minimal ACTH and β-endorphin levels at midnight and cortisol levels at 02.00 h. The general temporal structure of all hormonal secretions coincided in the two groups. However, whereas all measured ACTH/cortisol levels were quantitatively similar in the two groups, plasma β-endorphin concentrations were significantly higher in bulimic than in control subjects at all examined time points. The enhancement in the overall 24-hour β-endorphin secretion suggests the presence of an increased opioid tonus in bulimic women, which might play a role in the pathophysiology of the eating disorder.

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“…and 15 studies of medication trials (Agras, Dorian, Kirkely, Arnow, & Bachman, 1987;Barlow, Blouin, Blouin, & Perez, 1988;Blouin et al, 1988;Fluoxetine Bulimia Nervosa Collaborative Study Group, 1992;Horne et al, 1988;Hsu, Clement, Santhuse, & Ju, 1991;Hughes, Wells, Cunningham, & Ilstrup, 1986;Kennedy et al, 1988;Mitchell et al, 1989;Mitchell & Groat, 1984;Pope, Hudson, Jonas, & Yurgelun-Todd, 1983;Pope, Keck, McElroy, & Hudson, 1989;Sabine, Yonace, Farrington, Barratt, & Wakeling, 1983;Walsh et al, 1988;Walsh, Hadigan, Devlin, Gladis, & Roose, 1991). Analyses were categorized using the system provided by Everitt (1987).…”

mentioning

confidence: 99%

Survival analysis of response to group psychotherapy in bulimia nervosa

Crosby

Mitchell

Raymond

et al. 1993

Int. J. Eat. Disord.

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A reanalysis of treatment response and relapse was performed using survival analysis in a 12‐week clinical trial of cognitive behavioral group psychotherapy for the treatment of bulimia nervosa. One hundred forty‐three (143) bulimic women with high incidence of binge eating, self‐induced vomiting, and/or laxative abuse were randomly assigned to one of four possible treatment conditions that consisted of a combination of two factors: (1) emphasis on abstinence (high and low), and (2) treatment intensity (high and low). “Initial” and “maintained” response to treatment based on “total” and “near” abstinence criteria were determined using self‐reported binge eating, vomiting, and laxative use data. Results suggest that an emphasis on abstinence appears important in achieving initial abstinence, whereas in‐tensity of treatment may be important in maintaining abstinence. © 1993 by John Wiley & Sons, Inc.

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A Placebo-Controlled, Double-Blind Crossover Study of Naltrexone Hydrochloride in Outpatients with Normal Weight Bulimia

Cited by 99 publications

References 0 publications

Drug Treatment for Bulimia nervosa

Drug Treatment for Bulimia nervosa

Circadian Variations in Plasma ACTH, Cortisol and β-Endorphin Levels in Normal-Weight Bulimic Women

Survival analysis of response to group psychotherapy in bulimia nervosa

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