A Placebo‐Controlled Crossover Trial Using Trazodone in Pediatric Migraine

Battistella, Pier Antonio; Ruffilli, R.; Cernetti, R.; Pettenazzo, Andrea; Baldin, Lorella; Bertoli, Silvio; Zacchello, Franco

doi:10.1111/j.1526-4610.1993.hed3301036.x

Cited by 66 publications

(23 citation statements)

References 2 publications

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“…Trazodone was reported to be efficacious in the treatment of pédiatrie migraine in a double-blind placebo-controlled study (Battistella et al 1993). However, in the absence of reliable data on comorbidity, the mechanism by which trazodone produced sleep improvement in our sample remains unknown.…”

Section: Mechanism Of Insomnia Resolutionmentioning

confidence: 97%

Trazodone Is Only Slightly Faster Than Fluoxetine in Relieving Insomnia in Adolescents with Depressive Disorders

Kallepalli

Bhatara²,

Fogas³

et al. 1997

Journal of Child and Adolescent Psychopharmacology

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This retrospective chart review examined the relative effectiveness of fluoxetine and trazodone in relieving insomnia associated with depressive disorders in adolescents (aged 13-17 years). We reviewed the hospital charts of consecutively admitted adolescents with a depressive disorder and insomnia, who received one of three treatments: fluoxetine (20 +/- 2.2 mg), trazodone (71 +/- 32 mg), or a fluoxetine-trazodone combination (fluoxetine 29 +/- 2.2 mg, trazodone 68 +/- 29 mg). Each treatment was examined in 20 patients. Insomnia was defined as a change in sleep patterns characterized by decreased total sleep time that was sufficient to cause clinical concern, and insomnia resolution was defined as sleep starting by midnight and lasting 6 hours. Mean time to resolution of insomnia was significantly faster in adolescents treated with trazodone rather than fluoxetine (2.5 vs. 5.1 days, p < 0.05). Trazodone seemed to save only about 3 days and insomnia resolved in all subjects by the 11th day of antidepressant treatment. Median time to insomnia resolution was 2 days (range 1-5 days) in the trazodone group and 4 days (range 1-11 days) in the fluoxetine group. This difference between trazodone and fluoxetine, although statistically significant, was generally not clinically significant in the management of insomnia associated with depressive disorders in adolescents. The resolution of insomnia was not faster for treatment with a combination of fluoxetine and trazodone in comparison to fluoxetine monotherapy. Insomnia resolution was slightly later in older children. These clinical findings await confirmation by a controlled study. Both drugs seemed effective in ameliorating sleep symptoms in this sample, although it is likely that they produced these changes by different mechanisms.

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Section: Mechanism Of Insomnia Resolutionmentioning

confidence: 97%

Trazodone Is Only Slightly Faster Than Fluoxetine in Relieving Insomnia in Adolescents with Depressive Disorders

Kallepalli

Bhatara²,

Fogas³

et al. 1997

Journal of Child and Adolescent Psychopharmacology

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“…Trazodone A recent report confirms the effectiveness of trazodone for treatment of headache, in particular migraine in children [24]. The recommended dosage of 1 mg/kg body weight generally does not cause any side effects.…”

Section: Prophylaxismentioning

confidence: 86%

Pharmacological and behavioral treatment of pediatric migraine and tension-type headache

Grazzi¹,

D’Amico²,

Leone³

et al. 1998

Ital J Neuro Sci

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The problem concerning the treatment of pediatric headache has been the object of several recent reports. Some of the same medications used to treat adult headache problems are also utilized with children but usually at smaller dosages and in different combinations. The recent application of behavioral approaches, in particular biofeedback, for treatment of children's headaches has been an effective alternative to drugs without the problematic and dangerous side effects of pharmacological treatments. The purpose of this review is to give some indications about the most common pharmacological therapies for migraine and tension-type headache in children, and also to discuss the use of behavioral therapies, in particular biofeedback, as excellent alternatives to drugs.

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“…One placebo-controlled, crossover trial showed that trazodone might be effective in pediatric migraine prophylaxis [28]. There are case reports, but no controlled trials, that show trazodone as the prophylactic medication among adult migraineurs.…”

Section: Discussionmentioning

confidence: 98%

Antidepressants in the treatment of migraine headache

Punay

Couch

2003

Current Science Inc

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Antidepressants, particularly tricyclic antidepressants, have been a mainstay in the prophylactic therapy of migraine. The tricyclic antidepressants amitriptyline, nortriptyline, and doxepin have been the major agents for prophylactic treatment of migraine. These cause significant side effects in some patients. The high-affinity selective serotonin reuptake inhibitors and other newer antidepressants have been disappointing and much less effective in the treatment of migraine. In patients who are depressed with severe migraine, a tricyclic antidepressant may treat both conditions; however, the addition of a newer atypical antidepressant may be needed.

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A Placebo‐Controlled Crossover Trial Using Trazodone in Pediatric Migraine

Cited by 66 publications

References 2 publications

Trazodone Is Only Slightly Faster Than Fluoxetine in Relieving Insomnia in Adolescents with Depressive Disorders

Trazodone Is Only Slightly Faster Than Fluoxetine in Relieving Insomnia in Adolescents with Depressive Disorders

Pharmacological and behavioral treatment of pediatric migraine and tension-type headache

Antidepressants in the treatment of migraine headache

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