A placebo-controlled crossover study of oral clonidine in acute anorexia nervosa

Rc, Casper; Rf, Schlemmer; Ji, Javaid

doi:10.1016/0165-1781(87)90085-0

Cited by 47 publications

(10 citation statements)

References 47 publications

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“…Basic research has shown that the alpha 2 adrenergic agonist clonidine may increase feeding behavior, making a case to try this medication in AN [43]. However, this medication administered in a placebo-controlled crossover design had no beneficial effect in AN but was associated with hemodynamic side effects such as hypotension [44]. …”

Section: Medication Studies In Anmentioning

confidence: 99%

The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects

Frank

Shott

2016

CNS Drugs

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Anorexia nervosa is a severe psychiatric disorder without approved medication intervention. Every class of psychoactive medication has been tried to improve treatment outcome; however, randomized controlled trials have been ambiguous at best and across studies have not shown robust improvements in weight gain and recovery. Here we review the available literature on pharmacological interventions since anorexia nervosa came to greater public recognition in the 1960s. This will include a critical review of why those trials may not have been successful. We further provide a neurobiological background for the disorder and discuss how cognition, learning and emotion-regulating circuits could become treatment targets in the future. Making every effort to develop effective pharmacological treatment options for anorexia nervosa is imperative, as it continues to be a complex psychiatric disorder with high disease burden and mortality.

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Section: Medication Studies In Anmentioning

confidence: 99%

The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects

Frank

Shott

2016

CNS Drugs

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“…Oral clonidine was administered to a small sample (n = 4) of treatment-resistant patients, with negative results. 60 Goldberg et al 61 used cyproheptadine (CYP), in a randomized placebo-controlled trial with 4 arms (n = 81). No clinically significant effect on weight gain with CYP was found, even at 32 mg/day.…”

Section: Other Pharmacological Treatmentsmentioning

confidence: 99%

Psychopharmacological options for adult patients with anorexia nervosa

et al. 2015

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The aim of this review was to summarize evidence from research on psychopharmacological options for adult patients with anorexia nervosa (AN). Database searches of MEDLINE and PsycINFO (from January 1966 to January 2014) were performed, and original articles published as full papers, brief reports, case reports, or case series were included. Forty-one papers were screened in detail, and salient characteristics of pharmacological options for AN were summarized for drug classes. The body of evidence for the efficacy of pharmacotherapy in AN was unsatisfactory, the quality of observations was questionable (eg, the majority were not blinded), and sample size was often small. More trials are needed, while considering that nonresponse and nonremission are typical of patients with AN.

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“…Estudos com sulpirida (Vandereycken, 1984), carbonato de lítio (Gross et al, 1981), pimozida (Vandereycken & Pieerloot, 1982), tetrahidrocanabinol (Gross et al, 1983), clonidina (Casper et al, 1987) e cisaprida (Stacher et al, 1993) não apresentaram resultados favoráveis.…”

Section: Anorexia Nervosaunclassified

Tratamento farmacológico de transtornos alimentares

Salzano¹,

Córdas²

2004

Rev. psiquiatr. clín.

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A placebo-controlled crossover study of oral clonidine in acute anorexia nervosa

Cited by 47 publications

References 47 publications

The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects

The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects

Psychopharmacological options for adult patients with anorexia nervosa

Tratamento farmacológico de transtornos alimentares

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