A PK-PD model-based assessment of sugammadex effects on coagulation parameters

Bosch, Rolien; Lierop, Marie-José van; Kam, Pieter-Jan de; Kruithof, Annelieke C.; Burggraaf, Jacobus; Greef, Rik de; Visser, Sandra A.G.; Johnson‐Levonas, Amy O.; Kleijn, Huub-Jan

doi:10.1016/j.ejps.2015.12.028

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Nine studies were finally selected to assess the effect of sugammadex in aPTT and PT. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram describing the steps of study selection can be found in Figure 1 [ 16 ].…”

Section: Reviewmentioning

confidence: 99%

The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

Samara¹,

Stamatiou²,

Balanika³

et al. 2021

Cureus

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Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials' findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.

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Section: Reviewmentioning

confidence: 99%

The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

Samara¹,

Stamatiou²,

Balanika³

et al. 2021

Cureus

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Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat

Wong

Ilkova

Wijk

et al. 2018

European Journal of Pharmaceutical Sciences

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For the first time a predictive model that could describe the quantitative in vivo relationship between dose, PK and D2 RO of raclopride in non-anesthetized rat was established. The PK-RO model could facilitate the selection of optimal dose and dosing time when raclopride is used as tracer or as pharmacological blocker in various rat studies. The LC-MS based approach, which doses and quantifies a non-radiolabeled tracer, could be useful in evaluating the systemic disposition and brain kinetics of tracers.

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Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

Zhao¹,

Jie-yu²,

Xiong³

et al. 2021

DDDT

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Background Sugammadex has been a revolutionary reversal of neuromuscular blockade. It is known to be highly efficient. However, a change in the coagulation profile is one of the most dangerous potential complications which is a concern for both surgeon and anesthetist. Bleeding may cause hypovolemic shock, hematoma, and so on. To investigate the effects of sugammadex on coagulation profiles in patients with thyroidectomy, we compared patients that were treated with either sugammadex or neostigmine. Patients and Methods Eighty patients with thyroid neoplasms undergoing thyroidectomy were randomly allocated to sugammadex group (group S) or neostigmine group (group N). Induction of anesthesia was preformed using propofol, sufentanil, and rocuronium. Group S received sugammadex 2.0mg/kg after trachea intubation, similarly Group N received neostigmine 40 µg/kg, for reversal of rocuronium-induced neuromuscular blockade. The intraoperative coagulation profiles were monitored after the rocuronium injection (T0), 10 minutes after reversal (T1) and 30 minutes after reversal (T2) by testing activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), thrombin time (TT), and TEG-Haemonetics. Amount of bleeding was recorded during perioperative period. Results There was no significant difference in the thromboelastogram, APTT, PT, FIB, or TT measurements at each time point in Group N. The reaction time (R time) and kinetics time (K time) of Group S in T1 were significantly longer than the corresponding times at T0 and T2, and the R times were significantly longer than those in Group N at the same time points (P<0.05). Additionally, in Group S, the APTT was prolonged in T1 and returned to normal in T2. Conclusion The result showed that sugammadex provided transient efficacy in prolonging the coagulation parameters, while neostigmine did not change the coagulation profile.

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A PK-PD model-based assessment of sugammadex effects on coagulation parameters

Cited by 3 publications

References 15 publications

The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

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