A Pilot Study Utilizing Intraoperative Lymphoscintigraphy for Identification of the Sentinel Lymph Nodes in Vulvar Cancer

DeCesare, Steven; Fiorica, James V.; Robert, W S; Reintgen, Douglas S.; Arango, Hector; Hoffman, M S; Puleo, Christopher A.; Cavanagh, Denis

doi:10.1097/00128360-199804000-00012

Cited by 108 publications

(21 citation statements)

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“…In lesions with close proximity to the inguinal region, it is better to limit the amount of injected saline containing 99m Technetium and employ the blue dye technique. (53) 6/21 2/6 (33) DeCesare (54) 3/10 2/3 (67) b de Hullu (56) 27/59 0/2 (0) Rodier (57) 1/7 1/1 (100) Terada (60) 3/9 3/3 (100) De Cicco (61) 8 removal of the node most likely to harbor subclinical disease and thus define the extent of the superficial inguinal lymphadenectomy. In addition, ultrastaging procedures allow identification of micrometastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…The significance of SN biopsy in the management of malignant melanoma has been confirmed in a large number of studies (46) . The SN concept has also been extended to breast cancer (47)(48)(49)(50) and, more recently, to vulvar cancer (51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63) .…”

Section: The Sentinel Node Conceptmentioning

confidence: 99%

“…In vulvar cancer, lymphoscintigraphy has proved to be a suitable method to study the lymphatic pathways of the vulva (23,51) . The combination of this technique with gamma-probe guided surgery was also reported to be feasible for the identification of the SN in squamous cell cancer and melanoma of the vulva (54)(55)(56)(57)(58)(59)(60)(61)(62)(63) . The same technique was successfully adopted at our institutions in all six patients (Figs.…”

Section: The Sentinel Node Conceptmentioning

confidence: 99%

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Surgical management of stage I and II vulvar cancer: The role of the sentinel node biopsy. Review of literature

Makar

Scheistrøen

Weyngaert

et al. 2001

Int J Gynecol Cancer

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Abstract.Makar APH, Scheistroen M, van den Weyngaert D, Tropé CG. Surgical management of stage I and II vulvar cancer: The role of the sentinel node biopsy. Review of literature.Recognition of the psychosexual consequences of radical vulvectomy and better understanding of the lymphatic drainage and histopathologic features of vulvar cancer have led to a more conservative surgical approach, especially in patients with early-stage disease. Every patient with early vulvar cancer should be managed individually and the risk of conservative therapy balanced against the dangers and advantages of more radical therapy. The results of the sentinel node (SN) procedure in early cancer of the vulva are encouraging, and it might be possible in the near future to avoid the morbidity of inguino-femoral lymphadenectomy. This article reviews surgical management of early vulvar cancer and the place of SN biopsy.

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Section: Discussionmentioning

confidence: 99%

Section: The Sentinel Node Conceptmentioning

confidence: 99%

Section: The Sentinel Node Conceptmentioning

confidence: 99%

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Surgical management of stage I and II vulvar cancer: The role of the sentinel node biopsy. Review of literature

Makar

Scheistrøen

Weyngaert

et al. 2001

Int J Gynecol Cancer

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“…Barton (12)(13)(14) confirmed that selective lymphadenectomy of sentinel nodes preoperatively radiolabeled by lymphoscintigraphy can effectively predict the histopathology of the other regional nodes.…”

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confidence: 94%

Radioguided sentinel lymph node detection in vulvar cancer

Merisio

Berretta

Gualdi

et al. 2005

Int J Gynecol Cancer

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Lymph node status is the most important prognostic factor in vulvar cancer. Histologically, sentinel nodes may be representative of the status of the other regional nodes. Identification and histopathologic evaluation of sentinel nodes could then have a significant impact on clinical management and surgery. The aim of this study was to evaluate the feasibility and diagnostic accuracy of sentinel lymph node detection by preoperative lymphoscintigraphy with technetium-99 m–labeled nanocolloid, followed by radioguided intraoperative detection. Nine patients with stage T1, N0, M0, and 11 patients with stage T2, N0, M0 squamous cell carcinoma of the vulva were included in the study. Only three cases had lesions exceeding 3.5 cm in diameter. Sentinel nodes were detected in 100% of cases. A total of 30 inguinofemoral lymphadenectomies were performed, with a mean of 10 surgically removed nodes. Histological examination revealed 17 true negative sentinel nodes, 2 true positive, and 1 false negative. In our case series, sentinel lymph node detection had a 95% diagnostic accuracy, with only one false negative. Based on literature evidence, the sentinel node procedure is feasible and reliable in vulvar cancer; however, the value of sentinel node dissection in the treatment of early-stage vulvar cancer still needs to be confirmed.

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“…The sentinel lymph node biopsy is rapidly gaining popularity as a staging procedure for several solid tumours such as melanoma, 1 2 vulvar carcinoma, 3 penile cancer, 4 colorectal cancer, 5 neuroendocrine skin cancer, 6 squamous cell cancer of the scrotum, 7 and particularly breast cancer. [8][9][10] It enables selective targeting of the first tumour draining lymph node, where the initial metastases will form.…”

mentioning

confidence: 99%

Histopathological workup of sentinel lymph nodes: how much is enough?

Diest¹

1999

J Clin Pathol

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A Pilot Study Utilizing Intraoperative Lymphoscintigraphy for Identification of the Sentinel Lymph Nodes in Vulvar Cancer

Cited by 108 publications

References 0 publications

Surgical management of stage I and II vulvar cancer: The role of the sentinel node biopsy. Review of literature

Surgical management of stage I and II vulvar cancer: The role of the sentinel node biopsy. Review of literature

Radioguided sentinel lymph node detection in vulvar cancer

Histopathological workup of sentinel lymph nodes: how much is enough?

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