A pilot study using “ROPtool” to quantify plus disease in retinopathy of prematurity

Wallace, David K.; Zhao, Zheen; Freedman, Sharon F.

doi:10.1016/j.jaapos.2007.04.008

Cited by 98 publications

(90 citation statements)

References 17 publications

(18 reference statements)

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“…It is known that even larger infants in these settings may be at risk for severe ROP, presumably because of exposure to high levels of supplemental oxygen [24]. Therefore, accurate diagnosis of severe ROP using clinical and computer-based methods described in this study may become increasingly important [25][26][27][28]. (5) We note that one characteristic of AP-ROP is disease location in zone I or posterior zone II, which may be more difficult to analyze using existing computer-based image analysis systems.…”

Section: Discussionmentioning

confidence: 96%

Aggressive posterior retinopathy of prematurity: a pilot study of quantitative analysis of vascular features

Woo

Chan

Vinekar

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 96%

Aggressive posterior retinopathy of prematurity: a pilot study of quantitative analysis of vascular features

Woo

Chan

Vinekar

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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“…(4,5) A computer program ("ROPtool") has been developed that traces retinal blood vessels and measures their dilation and tortuosity. (6) Recently, a study was done to evaluate the accuracy of ROPtool in assessing tortuosity sufficient for plus disease in comparison to consensus of 3 experts. The accuracy of ROPtool was similar and its sensitivity was superior to individual examiners in assessing tortuosity sufficient for plus disease.…”

Section: Introductionmentioning

confidence: 99%

Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity

Wallace

Quinn

Freedman

et al. 2008

Journal of American Association for Pediatric Ophthalmology and

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139

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Purpose-Plus disease has become the major criterion for laser treatment in infants with retinopathy of prematurity (ROP), but its assessment is subjective. Our purpose was to compare quadrant-level and eye-level assessment of plus disease and pre-plus disease among 3 experienced ROP examiners and to report their rate of agreement.Methods-One hundred eighty-one high-quality RetCam images from premature infants were graded by 3 of the authors. Dilation and tortuosity were judged separately using a scale of normal or sufficiently abnormal to meet criteria for pre-plus or plus disease.

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“…Several studies have explored the possibility of automated plus disease detection by determining the diagnostic performance of image analysis algorithms compared to a reference standard of dilated ophthalmoscopy by an experienced examiner. [11][12][13][14] Yet no previous studies to our knowledge have attempted to measure the accuracy of experts for plus disease diagnosis, and to use this as a basis for analyzing performance of computer-based systems. * The purposes of this paper are to measure the accuracy of plus disease diagnosis by a group of recognized ROP experts, and to describe a pilot study exploring the diagnostic performance of a computer-based image analysis system, Retinal Image multiScale Analysis (RISA).…”

Section: Introductionmentioning

confidence: 99%

Plus disease in retinopathy of prematurity: Pilot study of computer-based and expert diagnosis

Gelman

Jiang

et al. 2007

Journal of American Association for Pediatric Ophthalmology and

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Purpose-To measure accuracy of plus disease diagnosis by recognized experts in retinopathy of prematurity (ROP), and to conduct a pilot study examining performance of a computer-based image analysis system, Retinal Image multiScale Analysis (RISA).Methods-Twenty-two ROP experts independently interpreted a set of 34 wide-angle retinal images for presence of plus disease. A reference standard diagnosis based on expert consensus was defined for each image. Images were analyzed by the computer-based system using individual and linear combinations of system parameters for arterioles and venules: integrated curvature (IC), diameter, and tortuosity index (TI). Sensitivity, specificity, and receiver operating characteristic areas under the curve (AUC) for plus disease diagnosis compared to the reference standard were determined for each expert, as well as for the computer-based system.Results-Expert sensitivity ranged from 0.308-1.000, specificity ranged from 0.571-1.000, and AUC ranged from 0.784-1.000. Among individual computer system parameters, venular IC had highest AUC (0.853). Among all computer system parameters, the linear combination of arteriolar IC, arteriolar TI, venular IC, venular diameter, and venular TI had highest AUC (0.967), which was greater than that of 18 (81.8%) of 22 experts.Conclusions-Accuracy of ROP experts for plus disease diagnosis is imperfect. A computer-based image analysis system has potential to diagnose plus disease with high accuracy. Further research

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A pilot study using “ROPtool” to quantify plus disease in retinopathy of prematurity

Cited by 98 publications

References 17 publications

Aggressive posterior retinopathy of prematurity: a pilot study of quantitative analysis of vascular features

Aggressive posterior retinopathy of prematurity: a pilot study of quantitative analysis of vascular features

Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity

Plus disease in retinopathy of prematurity: Pilot study of computer-based and expert diagnosis

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