A Pilot Study to Examine the Feasibility and Effects of a Home-Based Aerobic Program on Reducing Fatigue in Children With Acute Lymphoblastic Leukemia

Yeh, Chao Hsing; Wai, Jackson Pui Man; Lin, Un Shan; Chiang, Yi-Chien

doi:10.1097/ncc.0b013e3181e4553c

Cited by 108 publications

(132 citation statements)

References 31 publications

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“…Recently , Yeh et al, [40] recorded reduced levels of fatigue (P = 0.03, Cohen's d = 0.54) among children with ALL , who completed a 6-week home-based aerobic exercise program when compared to a control group , as well as Blaauwbroek et al, [41] demonstrated reduced levels of fatigue with increased levels of physical activity (P < 0.005, Cohen's d = -0.92 and 0.94 respectively) after 10 weeks of a homebased physical activity in childhood with cancer survivors. In addition to the results of a study by Keats and CulosReed [42] who revealed a reduction in fatigue (P = 0.01, Cohen's d = 0.69) after a 16-week group of physical activity intervention in survivors of pediatric cancer.…”

Section: Discussionmentioning

confidence: 99%

Impact of Aerobic Exercise on Physical Fitness and Fatigue in Children with Acute Lymphoblastic Leukemia

Baky¹,

Elhakk²

2017

International Journal of Therapies and Rehabilitation Research

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Section: Discussionmentioning

confidence: 99%

Impact of Aerobic Exercise on Physical Fitness and Fatigue in Children with Acute Lymphoblastic Leukemia

Baky¹,

Elhakk²

2017

International Journal of Therapies and Rehabilitation Research

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“…Our findings suggest that the first year of maintenance therapy should be targeted for preventive exercise and nutrition interventions, which will support the return to a healthy lifestyle. Several pilot studies have demonstrated feasibility of such an approach (23)(24)(25), but larger scale trials of efficacy are warranted. Schema for Children's Oncology Group Protocols (treated on or according to AALL0331 or AALL0232) with notation as to when corticosteroids and cranial radiation is given.…”

Section: Discussionmentioning

confidence: 99%

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Esbenshade¹,

Simmons²,

Koyama³

et al. 2011

JCO

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“…Five randomized, controlled trials have been identified (28)(29)(30)(31)33) and were ranked with evidence level "2b. " Six studies reached level "3b" as they included a control group but were not randomized (8,27,32,(34)(35)(36)). Six studies were classified level "4" (19-26) because they did not enroll a control group.…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

“…Review more patients (21,25,(27)(28)(29)(30)(31)(32)(33)(34). Five randomized, controlled trials have been identified (28)(29)(30)(31)33) and were ranked with evidence level "2b. "…”

Section: Exercise In Pediatric Oncologymentioning

confidence: 99%

Clinical exercise interventions in pediatric oncology: a systematic review

2013

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Studies in pediatric oncology have shown a positive effect of physical activity on disease-and treatment-related side effects. Although several reviews have approved the benefits of therapeutic exercise for adult cancer patients, no systematic review exists summarizing the evidence of physical activity in pediatric oncology. We identified a total of 17 studies using the PubMed database and Cochrane library. To evaluate the evidence, we used the evaluation system of the Oxford Center for Evidence-Based Medicine 2001. The findings confirm that clinical exercise interventions are feasible and safe, especially with acute lymphoblastic leukemia (ALL) patients and during medical treatment. No adverse effects have been reported. Positive effects were found on fatigue, strength, and quality of life. Single studies present positive effects on the immune system, body composition, sleep, activity levels, and various aspects of physical functioning. Child-specific aspects such as cognitive abilities, growth, adolescence, and reintegration into peer-groups, school, and sports have barely been taken into consideration. The evidence for exercise interventions in pediatric oncology is rated level "3. " Although the results are very promising, future research of high methodological quality and focusing on child-specific aspects is needed to establish evidence-based exercise recommendations, particularly for childhood cancer patients.A s a result of improved treatment regimes in pediatric oncology, the survival rates of children with cancer have risen to ~80% for 5-y survival (1-4). Therefore, the population of childhood cancer survivors is constantly growing. Despite these positive developments, childhood cancer is associated with a wide spectrum of various disease-and treatment-related side effects that may develop into chronic diseases and therefore result in long-term consequences. A negative impact on social, psychological, and physiological levels can be observed. Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).During the past few years, several studies have generated first hints describing holistic, positive effects of clinical exercise interventions in pediatric oncology. First results present an association between increased physical activity levels in childhood cancer patients and an improvement in quality of life (13). In particular, physical functioning is increased, anxiety is reduced, and social integration is encouraged (14). Considering the fact that physical activity plays a vital role in the physiological and psychosocial development of children, therapeutic exercise in pediatric oncology is particularly important. However, there is still a lack of comprehensive and evidence-based data in the field o...

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A Pilot Study to Examine the Feasibility and Effects of a Home-Based Aerobic Program on Reducing Fatigue in Children With Acute Lymphoblastic Leukemia

Abstract: It suggests that a home-based exercise program may reduce fatigue for ALL children who are undergoing maintenance chemotherapy.

Cited by 108 publications

References 31 publications

Impact of Aerobic Exercise on Physical Fitness and Fatigue in Children with Acute Lymphoblastic Leukemia

Impact of Aerobic Exercise on Physical Fitness and Fatigue in Children with Acute Lymphoblastic Leukemia

Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy.

Clinical exercise interventions in pediatric oncology: a systematic review

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